{"id":54565,"date":"2020-11-30T15:47:59","date_gmt":"2020-11-30T15:47:59","guid":{"rendered":"https:\/\/kc.multimarketing.dev\/cannabinoides\/"},"modified":"2020-12-29T15:36:30","modified_gmt":"2020-12-29T14:36:30","slug":"cannabinoides","status":"publish","type":"page","link":"https:\/\/www.kalapa-clinic.com\/pt-pt\/cannabinoides\/","title":{"rendered":"Cannabin\u00f3ides"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cannabin\u00f3ides<\/h2>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-1 one-column\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Os\u00a0<strong>canabin\u00f3ides<\/strong>\u00a0s\u00e3o um\u00a0<em>grupo de mol\u00e9culas<\/em>\u00a0que interagem com os\u00a0<strong>recetores do sistema endocanabinoide<\/strong>. S\u00e3o referidos como\u00a0<strong>endocanabinoides<\/strong>\u00a0se forem produzidos no nosso organismo como parte dos processos fisiol\u00f3gicos. Chamam-se\u00a0<strong>fitocanabinoides<\/strong>\u00a0quando s\u00e3o de origem vegetal e\u00a0<strong>canabin\u00f3ides sint\u00e9ticos<\/strong>\u00a0quando foram criados artificialmente em laborat\u00f3rio<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">No in\u00edcio, o termo canabinoide estava ligado aos compostos pr\u00f3prios da can\u00e1bis. Mas, agora, o conceito canabinoide \u00e9 dado a todos os produtos qu\u00edmicos que interagem com os recetores canabin\u00f3ides.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Habitualmente, o estudo dos canabinoides foca-se no\u00a0<a href=\"https:\/\/www.kalapa-clinic.com\/pt-pt\/sistema-endocanabinoide\/\"><strong>sistema endocanabinoide humano<\/strong><\/a>, mas, tendo em conta os seus mecanismos de a\u00e7\u00e3o e as possibilidades terap\u00eauticas que proporcionam, os investigadores tamb\u00e9m come\u00e7aram a estudar o\u00a0<strong>sistema endocanabinoide animal<\/strong>.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\t\t\t\t<div class=\"wp-block-uagb-table-of-contents uagb-toc__align-left uagb-toc__columns-1  uagb-block-48303b81      \"\n\t\t\t\t\tdata-scroll= \"1\"\n\t\t\t\t\tdata-offset= \"30\"\n\t\t\t\t\tstyle=\"\"\n\t\t\t\t>\n\t\t\t\t<div class=\"uagb-toc__wrap\">\n\t\t\t\t\t\t<div class=\"uagb-toc__title\">\n\t\t\t\t\t\t\tTudo sobre os Canabin\u00f3ides\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"uagb-toc__list-wrap \">\n\t\t\t\t\t\t<ol class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#cannabin\u00f3ides\" class=\"uagb-toc-link__trigger\">Cannabin\u00f3ides<\/a><li class=\"uagb-toc__list\"><a href=\"#infografias-sobre-como-funcionam-os-canabin\u00f3ides\" class=\"uagb-toc-link__trigger\">Infografias sobre como funcionam os canabin\u00f3ides<\/a><li class=\"uagb-toc__list\"><a href=\"#endocannabinoides\" class=\"uagb-toc-link__trigger\">Endocannabinoides<\/a><ul class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#endocannabinoides-que-han-sido-estudiados\" class=\"uagb-toc-link__trigger\">Endocannabinoides que han sido estudiados<\/a><\/li><\/ul><\/li><li class=\"uagb-toc__list\"><a href=\"#fitocanabinoides-del-cannabis\" class=\"uagb-toc-link__trigger\">Fitocanabinoides del Cannabis<\/a><li class=\"uagb-toc__list\"><a href=\"#o-efeito-entourage-dos-canabinoides\" class=\"uagb-toc-link__trigger\">O Efeito Entourage dos Canabinoides<\/a><li class=\"uagb-toc__list\"><a href=\"#cannabinoides-sint\u00e9ticos\" class=\"uagb-toc-link__trigger\">Cannabinoides sint\u00e9ticos<\/a><ul class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#bibliografia-sobre-canabin\u00f3ides\" class=\"uagb-toc-link__trigger\">Bibliografia sobre canabin\u00f3ides<\/a><\/ul><\/ul><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Infografias sobre como funcionam os canabin\u00f3ides<\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"826\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/ComoTrabajanCannabinoides-ES-1-1024x826.png\" alt=\"Kalapa Clinic\" class=\"wp-image-20549\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/ComoTrabajanCannabinoides-ES-1-1024x826.png 1024w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/ComoTrabajanCannabinoides-ES-1-300x242.png 300w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/ComoTrabajanCannabinoides-ES-1-768x619.png 768w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/ComoTrabajanCannabinoides-ES-1.png 1292w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Endocannabinoides<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Os\u00a0<strong>endocanabinoides<\/strong>\u00a0s\u00e3o\u00a0<strong>mol\u00e9culas produzidas pelo nosso corpo<\/strong>\u00a0que atuam como mensageiras atrav\u00e9s dos recetores canabinoides. Os mais importantes s\u00e3o a\u00a0<a href=\"https:\/\/www.kalapa-clinic.com\/en\/what-is-anandamide\/\"><strong>anandamida<\/strong><\/a>\u00a0e o 2-Araquidonil-glicerol (2-AG), pois ambos s\u00e3o sintetizados quando solicitados (os endocanabinoides n\u00e3o s\u00e3o armazenados no corpo, mas sim sintetizados onde e quando o organismo necessita deles para funcionar). Por outro lado, atuam nos seus respetivos recetores e s\u00e3o degradados pela enzima FAAH, todos no mesmo s\u00edtio de a\u00e7\u00e3o. N\u00e3o atuam de forma sist\u00e9mica, ou seja, atuam somente na localiza\u00e7\u00e3o exata do nosso corpo onde \u00e9 necess\u00e1rio um efeito espec\u00edfico e seletivo, dependendo do tipo de c\u00e9lula em que os\u00a0<strong><em>recetores endocanabinoides s\u00e3o ativados<\/em><\/strong>.<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Nos \u00faltimos anos, o conhecimento acerca das implica\u00e7\u00f5es dos canabinoides em diferentes sistemas fisiol\u00f3gicos aumentou significativamente. Sabe-se tamb\u00e9m que o sistema endocanabinoide pode\u00a0<strong><em>influenciar os tr\u00eas sistemas b\u00e1sicos de regula\u00e7\u00e3o fisiol\u00f3gica<\/em><\/strong>: o sistema neurotransmissor, o sistema imunit\u00e1rio e o sistema end\u00f3crino.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Endocannabinoides que han sido estudiados<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>Anandamida (AEA)<\/li><li>2-Araquidonil-glicerol (2-AG),<\/li><li>Noladina<\/li><li>Virodamida<\/li><li>N-araquidonil dopamina<\/li><\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n<div class=\"container genesis-custom-block \">\n\t<div class=\"row\">\n     <div class=\"col-12 text-center\">\n        <h2 class=\"sec-title wow fadeInUp introtitle\" style=\"visibility: visible; animation-name: fadeInUp;\">\n              <span><\/span>\n         <\/h2>\n         <div class=\"introsubtitle sec-title\">Quer saber mais sobre canabin\u00f3ides?<\/div>\n              <p class=\"wow fadeInUp introdescription\" style=\"visibility: visible; animation-name: fadeInUp;\">\n                            Temos uma equipa de especialistas \u00e0 espera para responder a quaisquer perguntas              <\/p>\n         <\/div>\n     <\/div>\n<\/div>\n\n\n\n\n<div style=\"display: none;\" id=\"treatment_popup_form\">\n\t<div class=\"container\">\n    \t<div class=\"row\">\n        \t<div class=\"col-lg-12\">\n\t\t\t\t<h2>Receber mais informa\u00e7\u00f5es<\/h2>\n\t\t\t\t<p>Deixe os seus dados abaixo e n\u00f3s enviar-lhe-emos informa\u00e7\u00f5es sobre Cannabin\u00f3ides.<\/p>\n\t\t\t<\/div>\n\t\t\t<!--<div class=\"col-lg-4\">\n\t\t\t\t<div class=\"f-logo\">\n\t\t\t\t\t<img decoding=\"async\" src=\"\/wp-content\/themes\/understrap\/assets\/images\/logo_kalapa_clinic_retina.png.webp\" alt=\"\">\n                <\/div>\n\t\t\t<\/div>-->\n\t\t<\/div>\n\t<\/div>\t\n\t<div role=\"form\" class=\"wpcf7\" id=\"wpcf7-f21340-o1\" lang=\"es-ES\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/pt-pt\/wp-json\/wp\/v2\/pages\/54565#wpcf7-f21340-o1\" method=\"post\" class=\"wpcf7-form init\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"21340\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"5.5.6\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"es_ES\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f21340-o1\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap your-name\"><input type=\"text\" name=\"your-name\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Nombre Completo*\" \/><\/span><\/p>\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\">\n     <span class=\"wpcf7-form-control-wrap tel-431\"><input type=\"tel\" name=\"tel-431\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-tel wpcf7-validates-as-tel\" aria-invalid=\"false\" placeholder=\"Tel\u00e9fono\" \/><\/span>\n   <\/div>\n<div class=\"wp-block-column\">\n    <span class=\"wpcf7-form-control-wrap your-email\"><input type=\"email\" name=\"your-email\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Tu Email*\" \/><\/span>\n   <\/div>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap text-pais\"><input type=\"text\" name=\"text-pais\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text\" aria-invalid=\"false\" placeholder=\"Pa\u00eds\" \/><\/span><br \/>\n<span class=\"wpcf7-form-control-wrap Padecimiento\"><input type=\"text\" name=\"Padecimiento\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Padecimiento*\" \/><\/span><\/p>\n<p><span class=\"wpcf7-form-control-wrap your-message\"><textarea name=\"your-message\" cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Tu mensaje\"><\/textarea><\/span><\/p>\n<p><input type=\"submit\" value=\"ENVIAR\" class=\"wpcf7-form-control has-spinner wpcf7-submit btn btn-green sndbtntreatment\" \/><\/p>\n<p><span class=\"wpcf7-form-control-wrap acceptance-LOPD\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><input type=\"checkbox\" name=\"acceptance-LOPD\" value=\"1\" aria-invalid=\"false\" \/><\/span><\/span><\/span> Si, acepto la <a style=\"color:#4da8ca;text-decoration:underline;\" href=\"\/politica-privacidad\/\">pol\u00edtica de privacidad<\/a> de Kalapa Clinic.<\/p>\n<p><FONT SIZE=1>Kalapa Clinic informa que los datos de car\u00e1cter personal que proporciones rellenando este formulario ser\u00e1n tratados por Grupo HS3 Project Development, S.L. como responsable de la web. La finalidad de la recogida y tratamiento de los datos personales que nos env\u00edas es para poder informarte sobre los servicios que ofrecemos sobre  tratamientos basados en cannabinoides. La legitimaci\u00f3n se realiza a trav\u00e9s del consentimiento del interesado. Te informamos que los datos que nos facilitas estar\u00e1n ubicados en servidores dentro de la Uni\u00f3n Europea. Podr\u00e1s ejercer tus derechos de acceso, rectificaci\u00f3n, limitaci\u00f3n y suprimir tus datos en cualquier momento. Puedes consultar la informaci\u00f3n adicional y detallada sobre la protecci\u00f3n de tus datos en nuestra <a href=\"https:\/\/www.kalapa-clinic.com\/politica-privacidad\/\"> pol\u00edtica de privacidad<\/a>. <\/FONT><\/p>\n<p style=\"display: none !important;\"><label>&#916;<textarea name=\"_wpcf7_ak_hp_textarea\" cols=\"45\" rows=\"8\" maxlength=\"100\"><\/textarea><\/label><input type=\"hidden\" id=\"ak_js_1\" name=\"_wpcf7_ak_js\" value=\"178\"\/><script>document.getElementById( \"ak_js_1\" ).setAttribute( \"value\", ( new Date() ).getTime() );<\/script><\/p><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div><div data-component=\"cf7rs-success\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Thank you!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><div data-component=\"cf7rs-error\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Error detected!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><\/form><\/div>\t<\/div>\n\n\n\n<div class=\"row justify-content-center\">\n\t<div class=\"col-lg-8 text-center  wow fadeInUp\" style=\"visibility: visible; animation-name: fadeInUp;\">\n\t\t<a data-fancybox data-src=\"#treatment_popup_form\" href=\"javascript:;\" class=\"btn btn-grad btn-lg btn-round\">Pide m\u00e1s informaci\u00f3n sobre cannabinoides<\/a>\n\t<\/div>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">Fitocanabinoides del Cannabis<\/h2>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">As variedades da planta can\u00e1bis cont\u00eam cerca de 500 compostos qu\u00edmicos diferentes, dos quais cerca de 100 fazem parte da fam\u00edlia dos\u00a0<strong>fitocanabinoides<\/strong>\u00a0(Waseem, 2014). Os canabinoides mais estudados, do ponto de vista terap\u00eautico, s\u00e3o o\u00a0<a href=\"https:\/\/www.kalapa-clinic.com\/pt-pt\/tetra-hidrocanabinol\/\"><strong>delta-9-tetra-hidrocanabinol (THC)<\/strong><\/a>\u00a0e o\u00a0<a href=\"https:\/\/www.kalapa-clinic.com\/pt-pt\/canabidiol_canabis_medicinal\/\"><strong>Canabidiol (CBD)<\/strong><\/a>, embora os investigadores estejam a come\u00e7ar a investigar canabinoides como o\u00a0<strong>Canabinol (CBN), o Tetrahidrocanabivarin (THCV) e o Canabigerol (CBG)<\/strong>, pois apresentam caracter\u00edsticas de potencial interesse m\u00e9dico em diferentes estudos pr\u00e9-cl\u00ednicos.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Quando os canabinoides est\u00e3o na planta, eles est\u00e3o na sua\u00a0<em><strong>forma \u00e1cida<\/strong><\/em>. Nesse estado, o THC, por exemplo, n\u00e3o tem nenhum efeito psicoativo. Ap\u00f3s a aplica\u00e7\u00e3o do calor, passa pelo processo de descarboxila\u00e7\u00e3o e passa para a sua forma ativa, que possui propriedades psicoativas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Para al\u00e9m dos canabinoides contidos na planta, existem outros compostos qu\u00edmicos com potencial terap\u00eautico. \u00c9 de real\u00e7ar, em particular, os\u00a0<strong>terpen\u00f3ides<\/strong>, que s\u00e3o uma parte atribu\u00edda das propriedades organol\u00e9ticas da can\u00e1bis (McPartland et al., 2014). Existem tamb\u00e9m outras fam\u00edlias de compostos que ainda n\u00e3o foram estudadas, como os\u00a0<strong>flavonoides<\/strong>, os alcaloides, os fitoester\u00f3is, etc.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/efecto-sequito.png\" alt=\"efecto-sequito\" class=\"wp-image-20035\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/efecto-sequito.png 600w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/efecto-sequito-300x200.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">O Efeito Entourage dos Canabinoides<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A presen\u00e7a de uma quantidade t\u00e3o elevada de diferentes compostos na planta can\u00e1bis pode resultar em intera\u00e7\u00f5es farmacol\u00f3gicas,\u00a0<strong>sin\u00e9rgicas<\/strong>\u00a0ou\u00a0<strong>antag\u00f3nicas<\/strong>. Ao estudar estas intera\u00e7\u00f5es, observou-se que, tanto em termos de efic\u00e1cia quanto de toler\u00e2ncia, os tratamentos com\u00a0<strong>prepara\u00e7\u00f5es completas da planta foram mais promissores<\/strong>\u00a0do que o uso isolado de canabin\u00f3ides. Este efeito conjunto, denominado de efeito \u201cEntourage\u201d, foi descrito pela primeira vez, em 1998, por Raphael Mechoulam (Ben-Shabbat, 1998; Russo &amp; Taming, 2011). O melhor exemplo descrito at\u00e9 agora \u00e9 o par THC-CBD cuja combina\u00e7\u00e3o torna o THC mais bem distribu\u00eddo, aumenta a biodisponibilidade (o nosso corpo utiliza a quantidade dispon\u00edvel da forma mais eficaz) e reduz poss\u00edveis efeitos secund\u00e1rios (McPartland et al., 2014). Embora existam poucos estudos acerca desta mat\u00e9ria, acredita-se que o\u00a0<strong>efeito entourage<\/strong>\u00a0n\u00e3o se deva somente \u00e0s intera\u00e7\u00f5es entre os diferentes fitocanabinoides, mas tamb\u00e9m \u00e0 intera\u00e7\u00e3o funcional entre os componentes canabinoides e n\u00e3o canabinoides da planta, como os terpenos e os flavonoides.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O efeito de comitiva \u00e9 a interac\u00e7\u00e3o entre os fitocanabin\u00f3ides como o THC e os outros elementos presentes na planta. No caso da Cannabis Sativa L, as interac\u00e7\u00f5es entre terpenos, flavon\u00f3ides e no momento da ingest\u00e3o, com endocanabin\u00f3ides como a anandamida, est\u00e3o a ser estudadas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A falta de informa\u00e7\u00e3o sobre o efeito de comitiva foi o que levou o Dr. Ethan Russo da Universidade de Massachusetts a publicar um ensaio sobre a sinergia de fitocanabin\u00f3ides e terpenos em 2011.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Por vezes, h\u00e1 <strong>patologias que n\u00e3o podem ser tratadas apenas com um canabin\u00f3ide.<\/strong> A sinergia entre diferentes canabin\u00f3ides tamb\u00e9m produz o efeito de comitiva, muito \u00fatil para o tratamento de doen\u00e7as em que um \u00fanico componente n\u00e3o \u00e9 suficiente. Neste sentido, v\u00e1rias publica\u00e7\u00f5es argumentam que o THC explica os principais benef\u00edcios medicinais da cannabis, tais como o efeito analg\u00e9sico.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Contudo, existem outros estudos que apoiam que a CDB e outros componentes da can\u00e1bis conseguem sinergia com o THC, aumentando os seus benef\u00edcios, antagonizando os efeitos adversos, e produzindo menos toxicidade do que apenas com o THC.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A gama de<strong> efeitos dos fitocanabin\u00f3ides<\/strong> \u00e9 muito vasta e \u00e9 por isso que a sua aplicabilidade em futuras aplica\u00e7\u00f5es terap\u00eauticas precisa de ser mais investigada.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Do mesmo modo, estes dois terpenos e pineno podem ajudar a <strong>aumentar o efeito do THC na dem\u00eancia em doentes com Alzheimer<\/strong>. Linalool, juntamente com cariofileno e mirceno, pode aumentar os efeitos de v\u00e1rios canabin\u00f3ides nos problemas do sono. Finalmente, o cariofileno, o mirceno e o pineno podem ser \u00fateis na presta\u00e7\u00e3o de apoio adjuvante no tratamento de v\u00edcios<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Foram recentemente propostos quatro mecanismos b\u00e1sicos de sinergia (Wagner e Ulrich-Merzenich, 2009):<\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Efeitos multi-alvo<\/li><li>Efeitos farmacocin\u00e9ticos tais como melhor solubilidade ou biodisponibilidade<\/li><li>Interac\u00e7\u00f5es de agentes que afectam a resist\u00eancia bacteriana<\/li><li>Modula\u00e7\u00e3o dos efeitos adversos que podem ser alcan\u00e7ados pela comitiva<\/li><\/ol>\n\n\n<div class=\"container genesis-custom-block \">\n\t<div class=\"row\">\n     <div class=\"col-12 text-center\">\n        <h2 class=\"sec-title wow fadeInUp introtitle\" style=\"visibility: visible; animation-name: fadeInUp;\">\n              <span><\/span>\n         <\/h2>\n         <div class=\"introsubtitle sec-title\">Quer saber mais sobre canabin\u00f3ides?<\/div>\n              <p class=\"wow fadeInUp introdescription\" style=\"visibility: visible; animation-name: fadeInUp;\">\n                            Temos uma equipa de especialistas \u00e0 espera para responder a quaisquer perguntas              <\/p>\n         <\/div>\n     <\/div>\n<\/div>\n\n\n\n\n<div style=\"display: none;\" id=\"treatment_popup_form\">\n\t<div class=\"container\">\n    \t<div class=\"row\">\n        \t<div class=\"col-lg-12\">\n\t\t\t\t<h2>Receber mais informa\u00e7\u00f5es<\/h2>\n\t\t\t\t<p>Deixe os seus dados abaixo e n\u00f3s enviar-lhe-emos informa\u00e7\u00f5es sobre Cannabin\u00f3ides.<\/p>\n\t\t\t<\/div>\n\t\t\t<!--<div class=\"col-lg-4\">\n\t\t\t\t<div class=\"f-logo\">\n\t\t\t\t\t<img decoding=\"async\" src=\"\/wp-content\/themes\/understrap\/assets\/images\/logo_kalapa_clinic_retina.png.webp\" alt=\"\">\n                <\/div>\n\t\t\t<\/div>-->\n\t\t<\/div>\n\t<\/div>\t\n\t<div role=\"form\" class=\"wpcf7\" id=\"wpcf7-f21340-o2\" lang=\"es-ES\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/pt-pt\/wp-json\/wp\/v2\/pages\/54565#wpcf7-f21340-o2\" method=\"post\" class=\"wpcf7-form init\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"21340\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"5.5.6\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"es_ES\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f21340-o2\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap your-name\"><input type=\"text\" name=\"your-name\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Nombre Completo*\" \/><\/span><\/p>\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\">\n     <span class=\"wpcf7-form-control-wrap tel-431\"><input type=\"tel\" name=\"tel-431\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-tel wpcf7-validates-as-tel\" aria-invalid=\"false\" placeholder=\"Tel\u00e9fono\" \/><\/span>\n   <\/div>\n<div class=\"wp-block-column\">\n    <span class=\"wpcf7-form-control-wrap your-email\"><input type=\"email\" name=\"your-email\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Tu Email*\" \/><\/span>\n   <\/div>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap text-pais\"><input type=\"text\" name=\"text-pais\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text\" aria-invalid=\"false\" placeholder=\"Pa\u00eds\" \/><\/span><br \/>\n<span class=\"wpcf7-form-control-wrap Padecimiento\"><input type=\"text\" name=\"Padecimiento\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Padecimiento*\" \/><\/span><\/p>\n<p><span class=\"wpcf7-form-control-wrap your-message\"><textarea name=\"your-message\" cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Tu mensaje\"><\/textarea><\/span><\/p>\n<p><input type=\"submit\" value=\"ENVIAR\" class=\"wpcf7-form-control has-spinner wpcf7-submit btn btn-green sndbtntreatment\" \/><\/p>\n<p><span class=\"wpcf7-form-control-wrap acceptance-LOPD\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><input type=\"checkbox\" name=\"acceptance-LOPD\" value=\"1\" aria-invalid=\"false\" \/><\/span><\/span><\/span> Si, acepto la <a style=\"color:#4da8ca;text-decoration:underline;\" href=\"\/politica-privacidad\/\">pol\u00edtica de privacidad<\/a> de Kalapa Clinic.<\/p>\n<p><FONT SIZE=1>Kalapa Clinic informa que los datos de car\u00e1cter personal que proporciones rellenando este formulario ser\u00e1n tratados por Grupo HS3 Project Development, S.L. como responsable de la web. La finalidad de la recogida y tratamiento de los datos personales que nos env\u00edas es para poder informarte sobre los servicios que ofrecemos sobre  tratamientos basados en cannabinoides. La legitimaci\u00f3n se realiza a trav\u00e9s del consentimiento del interesado. Te informamos que los datos que nos facilitas estar\u00e1n ubicados en servidores dentro de la Uni\u00f3n Europea. Podr\u00e1s ejercer tus derechos de acceso, rectificaci\u00f3n, limitaci\u00f3n y suprimir tus datos en cualquier momento. Puedes consultar la informaci\u00f3n adicional y detallada sobre la protecci\u00f3n de tus datos en nuestra <a href=\"https:\/\/www.kalapa-clinic.com\/politica-privacidad\/\"> pol\u00edtica de privacidad<\/a>. <\/FONT><\/p>\n<p style=\"display: none !important;\"><label>&#916;<textarea name=\"_wpcf7_ak_hp_textarea\" cols=\"45\" rows=\"8\" maxlength=\"100\"><\/textarea><\/label><input type=\"hidden\" id=\"ak_js_2\" name=\"_wpcf7_ak_js\" value=\"154\"\/><script>document.getElementById( \"ak_js_2\" ).setAttribute( \"value\", ( new Date() ).getTime() );<\/script><\/p><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div><div data-component=\"cf7rs-success\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Thank you!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><div data-component=\"cf7rs-error\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Error detected!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><\/form><\/div>\t<\/div>\n\n\n\n<div class=\"row justify-content-center\">\n\t<div class=\"col-lg-8 text-center  wow fadeInUp\" style=\"visibility: visible; animation-name: fadeInUp;\">\n\t\t<a data-fancybox data-src=\"#treatment_popup_form\" href=\"javascript:;\" class=\"btn btn-grad btn-lg btn-round\">Pide m\u00e1s informaci\u00f3n sobre cannabinoides<\/a>\n\t<\/div>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cannabinoides sint\u00e9ticos<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Os\u00a0<strong>canabin\u00f3ides sint\u00e9ticos<\/strong>\u00a0s\u00e3o gerados, como o nome sugere, artificialmente, tendo em conta as qualidades dos endocanabinoides e dos fitocanabinoides.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">S\u00e3o extratos criados em laborat\u00f3rios e s\u00e3o c\u00f3pias das caracter\u00edsticas mais relevantes dos endocanabinoides, portanto, funcionam e s\u00e3o metabolizados nos recetores CB1 e CB2, mas n\u00e3o t\u00eam os mesmos efeitos que os fitocanabinoides ou endocanabinoides e n\u00e3o t\u00eam efeitos farmacol\u00f3gicos t\u00e3o potentes quanto os do THC (Mechoulam, 2016).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Os primeiros canabin\u00f3ides sint\u00e9ticos foram criados na d\u00e9cada de 70, para explorar e compreender as vias do sistema canabinoide end\u00f3geno.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Alguns canabin\u00f3ides sint\u00e9ticos, como o Dronabinol e a Nabilona, s\u00e3o utilizados, a n\u00edvel m\u00e9dico, para tratar n\u00e1useas e v\u00f3mitos provocados pelo tratamento com quimioterapia ou em casos de anorexia causada por imunodefici\u00eancias devido \u00e0s suas propriedades orex\u00edgenas.<\/p>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">O THC \u00e9 aprovado pela FDA para tratar n\u00e1useas e v\u00f3mitos causados pela quimioterapia em pessoas que n\u00e3o respondem a outros tratamentos. Tamb\u00e9m \u00e9 utilizado para estimular o apetite das pessoas seropositivas<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dronabinol (Marinol) \u00e9 a forma sint\u00e9tica de THC que se encontra como c\u00e1psulas, solu\u00e7\u00e3o oral ou inalada.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Por outro lado, em Espanha existe apenas um precedente para um medicamento composto de Tetrahydrocannabinol chamado Sativex. \u00c9 uma solu\u00e7\u00e3o farmacol\u00f3gica desenvolvida pela GW Pharma, composta de CBD e THC (propor\u00e7\u00e3o 1:1), indicada para o tratamento da dor e espasticidade em pessoas com esclerose m\u00faltipla. [3]<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nabilone (Cesamento) \u00e9 outra droga sint\u00e9tica aprovada THC utilizada para paliar v\u00f3mitos provocados pela quimioterapia<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/thca-thc.png\" alt=\"\" class=\"wp-image-18452\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/thca-thc.png 600w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/thca-thc-300x200.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption>Estructura Molecular del Tetrahidrocannabinol y el \u00e1cido tetrahidrocannabin\u00f3lico<\/figcaption><\/figure><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<div class=\"wp-block-group librarytreatments\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Bibliografia sobre canabin\u00f3ides<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">El Sohly M, Waseeem G. Constituents of Cannabis Sativa. In: Pertwee RG, editor.&nbsp;<a href=\"http:\/\/catnews.org\/FREE%20Pot%20Books\/Roger%20G.%20Pertwee%20-%20Handbook%20of%20Cannabis.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Handbook of Cannabis.<\/a>&nbsp;Oxford, United Kingdom: Oxford University Press; 2014. p. 3-22.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ben-Shabat S, Fride E, Sheskin T, Tamiri T, y cols.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9721036\" target=\"_blank\" rel=\"noreferrer noopener\">An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2- arachidonoyl-glycerol cannabinoid activity<\/a>. Eur J Pharmacol. 1998;353(1):23-31.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Russo EB.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21749363\" target=\"_blank\" rel=\"noreferrer noopener\">Taming THC: potential cannabis synergy and phytocanna- binoid-terpenoid entourage effects<\/a>. Br J Pharmacol. 2011;163(7):1344-64.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">McPartland JM, Russo EB.&nbsp;<a href=\"http:\/\/catnews.org\/FREE%20Pot%20Books\/Roger%20G.%20Pertwee%20-%20Handbook%20of%20Cannabis.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Non-Phytocannabinoid Constituents of Cannabis and Herbal Synergy.<\/a>&nbsp;In: Pertwee RG, editor. Hand- book of Cannabis. Oxford, United Kingdom: Oxford University Press; 2014. p. 280-95.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Mechoulam R.&nbsp;<a href=\"https:\/\/www.degruyter.com\/downloadpdf\/j\/jbcpp.2016.27.issue-3\/jbcpp-2015-0091\/jbcpp-2015-0091.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabis \u2013 the Israeli perspective<\/a>. J Basic Clin Physiol Pharmacol. 2016, 27(3):181-187<\/p>\n<\/div><\/div>\n\n\n<div class=\"container genesis-custom-block \">\n\t<div class=\"row\">\n     <div class=\"col-12 text-center\">\n        <h2 class=\"sec-title wow fadeInUp introtitle\" style=\"visibility: visible; animation-name: fadeInUp;\">\n              <span><\/span>\n         <\/h2>\n         <div class=\"introsubtitle sec-title\">Quer saber mais sobre canabin\u00f3ides?<\/div>\n              <p class=\"wow fadeInUp introdescription\" style=\"visibility: visible; animation-name: fadeInUp;\">\n                            Temos uma equipa de especialistas \u00e0 espera para responder a quaisquer perguntas              <\/p>\n         <\/div>\n     <\/div>\n<\/div>\n\n\n\n\n<div style=\"display: none;\" id=\"treatment_popup_form\">\n\t<div class=\"container\">\n    \t<div class=\"row\">\n        \t<div class=\"col-lg-12\">\n\t\t\t\t<h2>Receber mais informa\u00e7\u00f5es<\/h2>\n\t\t\t\t<p>Deixe os seus dados abaixo e n\u00f3s enviar-lhe-emos informa\u00e7\u00f5es sobre Cannabin\u00f3ides.<\/p>\n\t\t\t<\/div>\n\t\t\t<!--<div class=\"col-lg-4\">\n\t\t\t\t<div class=\"f-logo\">\n\t\t\t\t\t<img decoding=\"async\" src=\"\/wp-content\/themes\/understrap\/assets\/images\/logo_kalapa_clinic_retina.png.webp\" alt=\"\">\n                <\/div>\n\t\t\t<\/div>-->\n\t\t<\/div>\n\t<\/div>\t\n\t<div role=\"form\" class=\"wpcf7\" id=\"wpcf7-f21340-o3\" lang=\"es-ES\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/pt-pt\/wp-json\/wp\/v2\/pages\/54565#wpcf7-f21340-o3\" method=\"post\" class=\"wpcf7-form init\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"21340\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"5.5.6\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"es_ES\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f21340-o3\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap your-name\"><input type=\"text\" name=\"your-name\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Nombre Completo*\" \/><\/span><\/p>\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\">\n     <span class=\"wpcf7-form-control-wrap tel-431\"><input type=\"tel\" name=\"tel-431\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-tel wpcf7-validates-as-tel\" aria-invalid=\"false\" placeholder=\"Tel\u00e9fono\" \/><\/span>\n   <\/div>\n<div class=\"wp-block-column\">\n    <span class=\"wpcf7-form-control-wrap your-email\"><input type=\"email\" name=\"your-email\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Tu Email*\" \/><\/span>\n   <\/div>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap text-pais\"><input type=\"text\" name=\"text-pais\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text\" aria-invalid=\"false\" placeholder=\"Pa\u00eds\" \/><\/span><br \/>\n<span class=\"wpcf7-form-control-wrap Padecimiento\"><input type=\"text\" name=\"Padecimiento\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Padecimiento*\" \/><\/span><\/p>\n<p><span class=\"wpcf7-form-control-wrap your-message\"><textarea name=\"your-message\" cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Tu mensaje\"><\/textarea><\/span><\/p>\n<p><input type=\"submit\" value=\"ENVIAR\" class=\"wpcf7-form-control has-spinner wpcf7-submit btn btn-green sndbtntreatment\" \/><\/p>\n<p><span class=\"wpcf7-form-control-wrap acceptance-LOPD\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><input type=\"checkbox\" name=\"acceptance-LOPD\" value=\"1\" aria-invalid=\"false\" \/><\/span><\/span><\/span> Si, acepto la <a style=\"color:#4da8ca;text-decoration:underline;\" href=\"\/politica-privacidad\/\">pol\u00edtica de privacidad<\/a> de Kalapa Clinic.<\/p>\n<p><FONT SIZE=1>Kalapa Clinic informa que los datos de car\u00e1cter personal que proporciones rellenando este formulario ser\u00e1n tratados por Grupo HS3 Project Development, S.L. como responsable de la web. La finalidad de la recogida y tratamiento de los datos personales que nos env\u00edas es para poder informarte sobre los servicios que ofrecemos sobre  tratamientos basados en cannabinoides. La legitimaci\u00f3n se realiza a trav\u00e9s del consentimiento del interesado. Te informamos que los datos que nos facilitas estar\u00e1n ubicados en servidores dentro de la Uni\u00f3n Europea. Podr\u00e1s ejercer tus derechos de acceso, rectificaci\u00f3n, limitaci\u00f3n y suprimir tus datos en cualquier momento. Puedes consultar la informaci\u00f3n adicional y detallada sobre la protecci\u00f3n de tus datos en nuestra <a href=\"https:\/\/www.kalapa-clinic.com\/politica-privacidad\/\"> pol\u00edtica de privacidad<\/a>. <\/FONT><\/p>\n<p style=\"display: none !important;\"><label>&#916;<textarea name=\"_wpcf7_ak_hp_textarea\" cols=\"45\" rows=\"8\" maxlength=\"100\"><\/textarea><\/label><input type=\"hidden\" id=\"ak_js_3\" name=\"_wpcf7_ak_js\" value=\"94\"\/><script>document.getElementById( \"ak_js_3\" ).setAttribute( \"value\", ( new Date() ).getTime() );<\/script><\/p><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div><div data-component=\"cf7rs-success\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Thank you!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><div data-component=\"cf7rs-error\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Error detected!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><\/form><\/div>\t<\/div>\n\n\n\n<div class=\"row justify-content-center\">\n\t<div class=\"col-lg-8 text-center  wow fadeInUp\" style=\"visibility: visible; animation-name: fadeInUp;\">\n\t\t<a data-fancybox data-src=\"#treatment_popup_form\" href=\"javascript:;\" class=\"btn btn-grad btn-lg btn-round\">Saber m\u00e1s<\/a>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Cannabin\u00f3ides Infografias sobre como funcionam os canabin\u00f3ides Endocannabinoides Os\u00a0endocanabinoides\u00a0s\u00e3o\u00a0mol\u00e9culas produzidas pelo nosso corpo\u00a0que atuam como mensageiras atrav\u00e9s dos recetores canabinoides. Os mais importantes s\u00e3o a\u00a0anandamida\u00a0e o 2-Araquidonil-glicerol (2-AG), pois ambos s\u00e3o sintetizados quando solicitados (os endocanabinoides n\u00e3o s\u00e3o armazenados no corpo, mas sim sintetizados onde e quando o organismo necessita deles para funcionar). Por outro [&#8230;]<\/p>\n<p><a class=\"understrap-read-more-link\" href=\"https:\/\/www.kalapa-clinic.com\/pt-pt\/cannabinoides\/\">Leia mais \u2192<\/a><\/p>\n","protected":false},"author":20,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/containerpage.php","meta":{"inline_featured_image":false,"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-54565","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Canabin\u00f3ides na marijuana medicinal | Kalapa Clinic<\/title>\n<meta name=\"description\" content=\"Os canabin\u00f3ides s\u00e3o os actores da terapia com marijuana medicinal para v\u00e1rias condi\u00e7\u00f5es, e aqui explicamos o seu modo de ac\u00e7\u00e3o e a sua qualidade terap\u00eautica.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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sobre como funcionam os canabin\u00f3ides Endocannabinoides Os\u00a0endocanabinoides\u00a0s\u00e3o\u00a0mol\u00e9culas produzidas pelo nosso corpo\u00a0que atuam como mensageiras atrav\u00e9s dos recetores canabinoides. 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Por outro&hellip;","_links":{"self":[{"href":"https:\/\/www.kalapa-clinic.com\/pt-pt\/wp-json\/wp\/v2\/pages\/54565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kalapa-clinic.com\/pt-pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kalapa-clinic.com\/pt-pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kalapa-clinic.com\/pt-pt\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kalapa-clinic.com\/pt-pt\/wp-json\/wp\/v2\/comments?post=54565"}],"version-history":[{"count":6,"href":"https:\/\/www.kalapa-clinic.com\/pt-pt\/wp-json\/wp\/v2\/pages\/54565\/revisions"}],"predecessor-version":[{"id":61533,"href":"https:\/\/www.kalapa-clinic.com\/pt-pt\/wp-json\/wp\/v2\/pages\/54565\/revisions\/61533"}],"wp:attachment":[{"href":"https:\/\/www.kalapa-clinic.com\/pt-pt\/wp-json\/wp\/v2\/media?parent=54565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}