{"id":55503,"date":"2019-08-29T21:16:39","date_gmt":"2019-08-29T20:16:39","guid":{"rendered":"https:\/\/kc.multimarketing.dev\/cannabis-medical-epidermolyse-bulleuse\/"},"modified":"2019-08-29T21:16:39","modified_gmt":"2019-08-29T20:16:39","slug":"cannabis-medical-epidermolyse-bulleuse","status":"publish","type":"post","link":"https:\/\/www.kalapa-clinic.com\/fr\/cannabis-medical-epidermolyse-bulleuse\/","title":{"rendered":"Cannabis m\u00e9dical pour l’\u00e9pidermolyse bulleuse"},"content":{"rendered":"

L’\u00e9pidermolyse bulleuse<\/strong> (EB) est un trouble cutan\u00e9<\/strong> caract\u00e9ris\u00e9 par la fragilit\u00e9 de la peau, \u00e9galement appel\u00e9e \u00ab\u00a0peau d’oignon\u00a0\u00bb. Cependant, la maladie peut se manifester dans de nombreux syst\u00e8mes organiques diff\u00e9rents.<\/p>\n

Par cons\u00e9quent, les enfants atteints d’\u00e9pidermolyse bulleuse peuvent b\u00e9n\u00e9ficier d’une prise en charge multidisciplinaire \u00e0 vie avec le soutien de dermatologues, cardiologues, h\u00e9matologues\/oncologues, n\u00e9phrologues, dentistes, ophtalmologues, sp\u00e9cialistes en nutrition, orthophonistes p\u00e9diatriques, neurologues, sp\u00e9cialistes en douleur, psychologues, travailleurs sociaux, pairs et soutien communautaire, chirurgiens, gastroent\u00e9rologues, m\u00e9decin-scientifique et scientifiques.<\/p>\n

Les traitements actuels visent \u00e0 restaurer l’int\u00e9grit\u00e9 de la peau par des th\u00e9rapies prot\u00e9iques, cellulaires et g\u00e9niques[1]<\/a>.<\/p>\n

L’\u00e9pidermolyse bulleuse est caus\u00e9e par des d\u00e9fauts d’ancrage des prot\u00e9ines entre l’\u00e9piderme et le derme, pr\u00e9disposant les patients aux bulles, ampoules, cicatrices et entra\u00eenant une fragilit\u00e9 m\u00e9canique de la peau. Il existe quatre sous-types d’EB<\/a> selon lesquels les prot\u00e9ines de la jonction dermo-\u00e9pidermique sont affect\u00e9es : l\u2019EB simplex, l\u2019EB jonctionnelle, l\u2019EB dystrophique et le syndrome de Kindler.<\/p>\n

Syst\u00e8me endocannabino\u00efde et \u00e9pidermolyse bulleuse<\/h2>\n

Le Cannabidiol (CBD) est le deuxi\u00e8me compos\u00e9 cannabino\u00efde le plus abondant trouv\u00e9 dans la plante de cannabis apr\u00e8s le T\u00e9trahydrocannabinol (THC). Le CBD n’a aucun effet psychotique et est devenu une alternative populaire pour les personnes souffrant de douleur chronique, d’anxi\u00e9t\u00e9 et de troubles du sommeil.<\/p>\n

Chez l’homme, deux principaux r\u00e9cepteurs cannabino\u00efdes, appel\u00e9s CB1 et CB2, ont \u00e9t\u00e9 identifi\u00e9s et interagissent avec le CBD. CB1 est principalement exprim\u00e9 dans le cerveau et la moelle \u00e9pini\u00e8re, tandis que les r\u00e9cepteurs CB2 sont exprim\u00e9s dans les cellules immunitaires. De plus, le CBD est aussi un agoniste direct des r\u00e9cepteurs vanillo\u00efdes, qui sont impliqu\u00e9s dans des processus comme la douleur, l’inflammation et la r\u00e9gulation de la temp\u00e9rature corporelle.<\/p>\n

Il a \u00e9t\u00e9 d\u00e9montr\u00e9 que les agents cannabino\u00efdes inhibent indirectement la prolif\u00e9ration des k\u00e9ratinocytes \u00e9pidermiques humains cultiv\u00e9s et stimulent leur apoptose<\/strong>. En fait, le traitement de l’acn\u00e9 vulgaire avec des cannabino\u00efdes en diminuant la prolif\u00e9ration des s\u00e9bocytes humains a \u00e9galement \u00e9t\u00e9 document\u00e9. Enfin, le r\u00e9cepteur CB1 a \u00e9galement \u00e9t\u00e9 impliqu\u00e9 dans la r\u00e9gulation de la diff\u00e9renciation \u00e9pidermique par inhibition de la transglutaminase, de la prot\u00e9ine kinase C et de la prot\u00e9ine d’activation-1.[2]<\/a><\/p>\n

Utilisation topique de l’huile de CBD chez les enfants atteints d’\u00e9pidermolyse bulleuse<\/h3>\n

En 2019, une \u00e9tude clinique a analys\u00e9 3 patients p\u00e9diatriques (6 mois, 3 ans et 10 ans) utilisant le CBD topique pour l’\u00e9pidermolyse bulleuse. Les r\u00e9sultats indiquent qu’un patient a cess\u00e9 de prendre des analg\u00e9siques opio\u00efdes oraux et que les trois patients ont signal\u00e9 une cicatrisation plus rapide, un soulagement de la douleur et moins de cloques. Cependant, d’autres essais cliniques \u00e0 double insu et randomis\u00e9s sont n\u00e9cessaires pour fournir des avantages scientifiques des cannabino\u00efdes pour l’\u00e9pidermolyse bulleuse[3]<\/a>.<\/p>\n

Administration sublinguale de CBD et de THC chez les adultes atteints d’EB<\/h3>\n

Les r\u00e9cepteurs CB1 et CB2 ont \u00e9t\u00e9 d\u00e9tect\u00e9s dans la peau humaine<\/strong> et aux extr\u00e9mit\u00e9s pr\u00e9synaptiques des circuits primaires de douleur aff\u00e9rente et sont co-localis\u00e9s avec des r\u00e9cepteurs mu-opio\u00efdes dans la jonction m\u00e9dullaire pour les neurones nociceptifs p\u00e9riph\u00e9riques. De plus, l’activation de CB2 sur les k\u00e9ratinocytes produit une r\u00e9ponse de blocage \u00e0 certaines r\u00e9actions nocives par la lib\u00e9ration d’opio\u00efdes endog\u00e8nes dans les tissus p\u00e9riph\u00e9riques.[4]<\/a><\/p>\n

En 2018, un article publi\u00e9 dans le British Journal of Dermatology<\/em> a \u00e9tudi\u00e9 trois patients atteints d’\u00e9pidermolyse bulleuse trait\u00e9s par THC sublingual et CBD<\/strong>, quatre fois par jour, en plus de leurs traitements pr\u00e9c\u00e9dents. Les trois patients ont signal\u00e9 une am\u00e9lioration du score de douleur, une r\u00e9duction de la prise globale d’analg\u00e9siques et une diminution du prurit. [5]<\/a><\/p>\n

Conclusion<\/h4>\n

Jusqu’\u00e0 pr\u00e9sent, les \u00e9tudes rapport\u00e9es sur des patients atteints d’EB montrent le potentiel des cannabino\u00efdes \u00e0 inhiber la prolif\u00e9ration de cellules \u00e9pidermiques dangereuses et \u00e0 induire leur apoptose, en plus d’att\u00e9nuer la douleur et la perception du prurit. N\u00e9anmoins, d’autres recherches et \u00e9tudes contr\u00f4l\u00e9es sont n\u00e9cessaires afin d’\u00e9valuer correctement les doses et la m\u00e9thode d’administration sp\u00e9cifique pour le traitement de cette maladie.<\/a><\/p>\n

[1]<\/a> Cohn, H. I., & Teng, J. M. C. (2016). Advancement in management of epidermolysis bullosa<\/a>. Current Opinion in Pediatrics, 28(4), 507\u2013516. doi:10.1097\/mop.0000000000000380<\/p>\n

[2]<\/a> Maccarrone M, Di Rienzo M, Battista N, Gasperi V, Guerrieri P, Rossi A, Finazzi-Agr\u00f2 A. (2003). The Endocannabinoid System in Human Keratinocytes<\/a>. The Journal of Biological Chemistry;278(36):33896-33903. Doi: 10.1074\/jbc.m303994200<\/p>\n

[3]<\/a> Chelliah, M. P., Zinn, Z., Khuu, P., & Teng, J. M. C. (2018).\u00a0Self-initiated use of topical cannabidiol oil for epidermolysis bullosa<\/a>. Pediatric Dermatology, 35(4), e224\u2013e227.<\/em>doi:10.1111\/pde.13545<\/p>\n

[4]<\/a> Russo EB.\u00a0Cannabinoids in the management of difficult to treat pain<\/a>.\u00a0Ther Clin Risk Manag<\/em>\u00a02008;\u00a04<\/strong>:245\u201359.<\/p>\n

[5]<\/a> Schr\u00e4der, N. H. B., Duipmans, J. C., Molenbuur, B., Wolff, A., & Jonkman, M. F. (2018).\u00a0Combined THC and CBD to treat pain in epidermolysis bullosa: a report of three cases<\/a>. British Journal of Dermatology.<\/em>\u00a0doi:10.1111\/bjd.17341<\/p>\n","protected":false},"excerpt":{"rendered":"

L’\u00e9pidermolyse bulleuse (EB) est un trouble cutan\u00e9 caract\u00e9ris\u00e9 par la fragilit\u00e9 de la peau, \u00e9galement appel\u00e9e \u00ab\u00a0peau d’oignon\u00a0\u00bb. Cependant, la maladie peut se manifester dans de nombreux syst\u00e8mes organiques diff\u00e9rents. Par cons\u00e9quent, les enfants atteints d’\u00e9pidermolyse bulleuse peuvent b\u00e9n\u00e9ficier d’une prise en charge multidisciplinaire \u00e0 vie avec le soutien de dermatologues, cardiologues, h\u00e9matologues\/oncologues, n\u00e9phrologues, dentistes, […]<\/p>\n

En savoir plus \u2192<\/a><\/p>\n","protected":false},"author":21,"featured_media":19042,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[3027,5058],"tags":[3198,4648,3151,4926,4715,4691],"class_list":["post-55503","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cannabis-medicinal","category-maladies-peau","tag-cannabidiol","tag-cannabis-medical","tag-cbd","tag-epidermolyse-bulleuse","tag-recepteurs-cannabinoides","tag-systeme-endocannabinoide"],"yoast_head":"\nCannabis m\u00e9dical pour l'\u00e9pidermolyse bulleuse | Kalapa Clinic<\/title>\n<meta name=\"description\" content=\"Selon de nouvelles d\u00e9couvertes, la CBD pourrait aider \u00e0 lutter contre les maladies de la peau comme l'\u00e9pidermolyse bulleuse chez les enfants et les adultes.\" \/>\n<meta name=\"robots\" content=\"index, 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