{"id":54261,"date":"2020-11-30T12:06:26","date_gmt":"2020-11-30T12:06:26","guid":{"rendered":"https:\/\/kc.multimarketing.dev\/receptores-cannabinoides\/"},"modified":"2021-01-19T16:24:10","modified_gmt":"2021-01-19T15:24:10","slug":"recepteurs-cannabinoides","status":"publish","type":"page","link":"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/","title":{"rendered":"R\u00e9cepteurs cannabino\u00efdes"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Les R\u00e9cepteurs Cannabino\u00efdes<\/h2>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-1 one-column\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Malgr\u00e9 l\u2019usage m\u00e9dical et r\u00e9cr\u00e9atif du cannabis durant des si\u00e8cles, l\u2019identit\u00e9 de son principal constituant psychotrope est rest\u00e9e inconnu jusqu\u2019en 1964, lorsque&nbsp;<strong>Rafael Mechoulam, Yechiel Gaoni et Habib Edery<\/strong>&nbsp;de l\u2019Institut de Sciences Weizmann \u00e0 Rehovot (Isra\u00ebl), isol\u00e8rent pour la premi\u00e8re fois le Delta-9-tetrahidrocannabinol (THC). Par la suite, on a \u00e9tabli que ce composant \u00e9tait responsable des effets psychotropes de la plante. Plus de deux d\u00e9cennies plus tard, on a d\u00e9couvert que l\u2019effet psychotrope se produisait gr\u00e2ce \u00e0&nbsp;<strong>l\u2019interaction des cannabino\u00efdes<\/strong>&nbsp;avec une&nbsp;<strong>s\u00e9rie de r\u00e9cepteurs<\/strong>&nbsp;sp\u00e9cifiques pr\u00e9sents dans&nbsp;<strong>les cellules nerveuses.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Les r\u00e9cepteurs cannabino\u00efdes (CB), ainsi que les endocannabino\u00efdes, constituent le syst\u00e8me endocannabino\u00efde, qui est essentiel au fonctionnement normal de l&rsquo;organisme. Vieux de plusieurs millions d&rsquo;ann\u00e9es, le syst\u00e8me endocannabino\u00efde n&rsquo;est pas seulement pr\u00e9sent chez l&rsquo;homme, mais a \u00e9galement \u00e9t\u00e9 identifi\u00e9 chez les mammif\u00e8res, les oiseaux, les amphibiens et d&rsquo;autres animaux.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ils agissent tous de la m\u00eame mani\u00e8re, par l&rsquo;interm\u00e9diaire des r\u00e9cepteurs de la SEC.<\/strong><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\t\t\t\t<div class=\"wp-block-uagb-table-of-contents uagb-toc__align-left uagb-toc__columns-1  uagb-block-c37833c2      \"\n\t\t\t\t\tdata-scroll= \"1\"\n\t\t\t\t\tdata-offset= \"30\"\n\t\t\t\t\tstyle=\"\"\n\t\t\t\t>\n\t\t\t\t<div class=\"uagb-toc__wrap\">\n\t\t\t\t\t\t<div class=\"uagb-toc__title\">\n\t\t\t\t\t\t\tTout sur les r\u00e9cepteurs cannabino\u00efdes\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"uagb-toc__list-wrap \">\n\t\t\t\t\t\t<ol class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#les-r\u00e9cepteurs-cannabino\u00efdes\" class=\"uagb-toc-link__trigger\">Les R\u00e9cepteurs Cannabino\u00efdes<\/a><li class=\"uagb-toc__list\"><a href=\"#infographie-des-r\u00e9cepteurs-cannabino\u00efdes\" class=\"uagb-toc-link__trigger\">Infographie des r\u00e9cepteurs cannabino\u00efdes<\/a><li class=\"uagb-toc__list\"><a href=\"#r\u00e9cepteurs-cannabino\u00efdes-d\u00e9couverts-jusqu\u00e0-pr\u00e9sent\" class=\"uagb-toc-link__trigger\">R\u00e9cepteurs cannabino\u00efdes d\u00e9couverts jusqu&#039;\u00e0 pr\u00e9sent<\/a><ul class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#liste-des-r\u00e9cepteurs-cannabino\u00efdes\" class=\"uagb-toc-link__trigger\">Liste des r\u00e9cepteurs cannabino\u00efdes<\/a><\/li><\/ul><\/li><li class=\"uagb-toc__list\"><a href=\"#les-r\u00e9cepteurs-cb1\" class=\"uagb-toc-link__trigger\">Les R\u00e9cepteurs CB1<\/a><li class=\"uagb-toc__list\"><a href=\"#les-r\u00e9cepteurs-cannabinoides-cb2\" class=\"uagb-toc-link__trigger\">Les R\u00e9cepteurs Cannabinoides CB2<\/a><li class=\"uagb-toc__list\"><a href=\"#les-r\u00e9cepteurs-5-ht1a\" class=\"uagb-toc-link__trigger\">Les R\u00e9cepteurs 5-HT1A<\/a><li class=\"uagb-toc__list\"><a href=\"#les-r\u00e9cepteurs-de-type-gpr55-et-gpr119\" class=\"uagb-toc-link__trigger\">Les R\u00e9cepteurs de type GPR55 et GPR119<\/a><li class=\"uagb-toc__list\"><a href=\"#le-r\u00e9cepteur-gpr55\" class=\"uagb-toc-link__trigger\">Le R\u00e9cepteur GPR55<\/a><li class=\"uagb-toc__list\"><a href=\"#les-r\u00e9cepteurs-gpr119\" class=\"uagb-toc-link__trigger\">Les R\u00e9cepteurs GPR119<\/a><ul class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#le-gpr119et-le-traitement-pour-lob\u00e9sit\u00e9\" class=\"uagb-toc-link__trigger\">\u00a0Le GPR119\u00a0et le traitement pour l\u2019ob\u00e9sit\u00e9<\/a><li class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#le-gpr119et-lhom\u00e9ostasie-du-glucose\" class=\"uagb-toc-link__trigger\">Le GPR119\u00a0et l\u2019hom\u00e9ostasie du glucose<\/a><li class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#le-gpr119et-ses-possibles-applications-dans-la-d\u00e9couverte-de-nouveaux-traitements\" class=\"uagb-toc-link__trigger\">Le GPR119\u00a0et ses possibles applications dans la d\u00e9couverte de nouveaux traitements<\/a><\/li><\/ul><\/li><\/ul><\/li><li class=\"uagb-toc__list\"><a href=\"#les-r\u00e9cepteurs-vanillo\u00efdes-\u00e0-potentiel-transitoire-ou-trpv\" class=\"uagb-toc-link__trigger\">Les R\u00e9cepteurs vanillo\u00efdes \u00e0 potentiel transitoire ou TRPV<\/a><ul class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#bibliographie-sur-les-r\u00e9cepteurs-cannabino\u00efdes\" class=\"uagb-toc-link__trigger\">Bibliographie sur les r\u00e9cepteurs cannabino\u00efdes<\/a><\/ul><\/ul><\/ul><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Infographie des r\u00e9cepteurs cannabino\u00efdes<\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"723\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-1024x723.jpg\" alt=\"Infografia Cannabidiol propiedades terapeuticas | Kalapa Clinic\" class=\"wp-image-21397\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-1024x723.jpg 1024w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-300x212.jpg 300w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-768x542.jpg 768w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK.jpg 1192w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">R\u00e9cepteurs cannabino\u00efdes d\u00e9couverts jusqu&rsquo;\u00e0 pr\u00e9sent<\/h2>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Ce n\u2019est qu\u2019en 1988, gr\u00e2ce \u00e0 des exp\u00e9riences utilisant le CP55940 radio-marqu\u00e9, que le premier de ces r\u00e9cepteurs fut finalement identifi\u00e9 (1). Ce r\u00e9cepteur appel\u00e9&nbsp;<strong>cannabino\u00efde 1 (CB1),<\/strong>&nbsp;se trouve principalement dans le&nbsp;<strong>Syst\u00e8me Nerveux Central (CNS)<\/strong>&nbsp;et les organes p\u00e9riph\u00e9riques (2).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Le second r\u00e9cepteur cannabino\u00efde (CB2)<\/strong>&nbsp;fut d\u00e9couvert en 1993 gr\u00e2ce \u00e0 des moyens techniques de clonage par homologie. Le r\u00e9cepteur CB2 se r\u00e9v\u00e8le \u00eatre diff\u00e9rent, tant dans la s\u00e9quence d\u2019acides amin\u00e9s que dans sa r\u00e9partition dans notre corps, en se trouvant principalement dans les tissus p\u00e9riph\u00e9riques en relation avec le syst\u00e8me immunitaire (sp\u00e9cialement dans les lymphocytes B) mais \u00e9galement, en moindre quantit\u00e9, dans le tissu nerveux (3).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Le THC est le lien principal des deux r\u00e9cepteurs ayant une affinit\u00e9 plus \u00e9lev\u00e9e avec les r\u00e9cepteurs CB1 que pour les CB2. (4)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Aujourd\u2019hui, nous savons qu\u2019il existe d\u2019autres r\u00e9cepteurs en relation avec le&nbsp;<a href=\"https:\/\/www.kalapa-clinic.com\/fr\/le-systeme-endocannabinoide\/\">syst\u00e8me endocannabino\u00efde<\/a>&nbsp;comme par exemple les r\u00e9cepteurs m\u00e9tabotropiques&nbsp;<strong>GPR55, GPR119, GPR18<\/strong>&nbsp;et les r\u00e9cepteurs vanillo\u00efdes \u00e0 potentiel transitoire (<strong>TRPV<\/strong>). (5)<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Liste des r\u00e9cepteurs cannabino\u00efdes<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>CB1<\/li><li>CB2<\/li><li>GPR55<\/li><li>GPR119<\/li><li>GPR18<\/li><li>TRPV<\/li><li>5-HT1A<\/li><\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n<div class=\"container genesis-custom-block \">\n\t<div class=\"row\">\n     <div class=\"col-12 text-center\">\n        <h2 class=\"sec-title wow fadeInUp introtitle\" style=\"visibility: visible; animation-name: fadeInUp;\">\n              <span><\/span>\n         <\/h2>\n         <div class=\"introsubtitle sec-title\">Vous voulez en savoir plus sur les r\u00e9cepteurs des cannabino\u00efdes ?<\/div>\n              <p class=\"wow fadeInUp introdescription\" style=\"visibility: visible; animation-name: fadeInUp;\">\n                            Une \u00e9quipe de sp\u00e9cialistes se tient \u00e0 votre disposition pour r\u00e9pondre \u00e0 vos questions              <\/p>\n         <\/div>\n     <\/div>\n<\/div>\n\n\n\n\n<div style=\"display: none;\" id=\"treatment_popup_form\">\n\t<div class=\"container\">\n    \t<div class=\"row\">\n        \t<div class=\"col-lg-12\">\n\t\t\t\t<h2>Recevoir plus d&rsquo;informations<\/h2>\n\t\t\t\t<p>Laissez vos coordonn\u00e9es ci-dessous et nous vous enverrons des informations sur R\u00e9cepteurs cannabino\u00efdes.<\/p>\n\t\t\t<\/div>\n\t\t\t<!--<div class=\"col-lg-4\">\n\t\t\t\t<div class=\"f-logo\">\n\t\t\t\t\t<img decoding=\"async\" src=\"\/wp-content\/themes\/understrap\/assets\/images\/logo_kalapa_clinic_retina.png.webp\" alt=\"\">\n                <\/div>\n\t\t\t<\/div>-->\n\t\t<\/div>\n\t<\/div>\t\n\t<div role=\"form\" class=\"wpcf7\" id=\"wpcf7-f54320-o1\" lang=\"fr-FR\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/fr\/wp-json\/wp\/v2\/pages\/54261#wpcf7-f54320-o1\" method=\"post\" class=\"wpcf7-form init\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"54320\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"5.5.6\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"fr_FR\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f54320-o1\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<\/div>\n<p><label> Nom et Pr\u00e9nom *<br \/>\n<span class=\"wpcf7-form-control-wrap your-name\"><input type=\"text\" name=\"your-name\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" \/><\/span> <\/label><\/p>\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\">\n<label style=\"color: #748494;\"> Votre adresse email *<br \/>\n    <span class=\"wpcf7-form-control-wrap your-email\"><input type=\"email\" name=\"your-email\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" \/><\/span><\/label>\n   <\/div>\n<div class=\"wp-block-column\">\n<label style=\"color: #748494;\"> Telephone<br \/>\n<span class=\"wpcf7-form-control-wrap phonetext-56\"><input type=\"text\" name=\"phonetext-56\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-phonetext\" aria-invalid=\"false\" \/><input type=\"hidden\" name=\"phonetext-56-country-code\" class=\"wpcf7-phonetext-country-code\" \/><\/span><\/label>\n   <\/div>\n<\/div>\n<p><label> Pays de r\u00e9sidence<br \/>\n<span class=\"wpcf7-form-control-wrap countrytext-664\"><input type=\"text\" name=\"countrytext-664\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-countrytext\" aria-invalid=\"false\" \/><\/span><\/label><br \/>\n<label> Maladie*<br \/>\n<span class=\"wpcf7-form-control-wrap Maladie\"><input type=\"text\" name=\"Maladie\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" \/><\/span><\/label><br \/>\n<label> Message<br \/>\n<span class=\"wpcf7-form-control-wrap your-message\"><textarea name=\"your-message\" cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\"><\/textarea><\/span><\/label><\/p>\n<p><span class=\"wpcf7-form-control-wrap acceptance-LOPD\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><input type=\"checkbox\" name=\"acceptance-LOPD\" value=\"1\" aria-invalid=\"false\" \/><\/span><\/span><\/span>  Oui, j'accepte la <a style=\"color:#4da8ca;text-decoration:underline;\" href=\"\/fr\/politique-de-confidentialite\/\">politique de confidentilit\u00e9.<\/a> de Kalapa Clinic.<\/p>\n<p><input type=\"submit\" value=\"ENVOYER\" class=\"wpcf7-form-control has-spinner wpcf7-submit btn btn-orange sndbtntreatment\" \/><\/p>\n<p><FONT SIZE=2>Kalapa Clinic vous informe que les donn\u00e9es \u00e0 caract\u00e8re personnel indiqu\u00e9es en compl\u00e9tant ce formulaire seront trait\u00e9es par Grupo HS3 Project Development, S.L. en tant que responsable du site web. La finalit\u00e9 de la collecte et du traitement des informations personnelles que vous nous envoyez est de pouvoir vous informez sur les services que nous offrons sur les traitements \u00e0 base de cannabino\u00efdes. La l\u00e9gitimit\u00e9 se r\u00e9alise \u00e0 travers votre consentement. Nous vous informons que les donn\u00e9es que vous nous confiez seront conserv\u00e9es sur des serveurs situ\u00e9s en Union Europ\u00e9enne. Vous pourrez exercer vos droits d'acc\u00e8s, de modification, de limitation et de suppression de vos donn\u00e9es \u00e0 n'importe quel moment. Vous pouvez consulter toutes les informations additionnelles et d\u00e9taill\u00e9es sur la protection des donn\u00e9es personnelles sur notre site web <a href=\"\/fr\/politique-de-confidentialite\/\">pol\u00edtica de privacidad.<\/a>. <\/FONT><\/p>\n<p style=\"display: none !important;\"><label>&#916;<textarea name=\"_wpcf7_ak_hp_textarea\" cols=\"45\" rows=\"8\" maxlength=\"100\"><\/textarea><\/label><input type=\"hidden\" id=\"ak_js_1\" name=\"_wpcf7_ak_js\" value=\"24\"\/><script>document.getElementById( \"ak_js_1\" ).setAttribute( \"value\", ( new Date() ).getTime() );<\/script><\/p><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div><div data-component=\"cf7rs-success\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Merci!&lt;\/h3&gt;\r\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\r\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"6000\" data-placement=\"in-modal\" ><\/div><div data-component=\"cf7rs-error\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Erreur d\u00e9tect\u00e9e!&lt;\/h3&gt;\r\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\r\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"6000\" data-placement=\"in-modal\" ><\/div><\/form><\/div>\t<\/div>\n\n\n\n<div class=\"row justify-content-center\">\n\t<div class=\"col-lg-8 text-center  wow fadeInUp\" style=\"visibility: visible; animation-name: fadeInUp;\">\n\t\t<a data-fancybox data-src=\"#treatment_popup_form\" href=\"javascript:;\" class=\"btn btn-grad btn-lg btn-round\">Demander plus d&rsquo;informations sur les cannabino\u00efdes<\/a>\n\t<\/div>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Les R\u00e9cepteurs CB1<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ils se trouvent principalement dans le Syst\u00e8me Nerveux Central (SNC), en plus grande proportion dans des ganglions basaux, le cervelet, le n\u00e9ocortex, et l\u2019hippocampe, qui est une zone essentielle dans le processus d\u2019apprentissage et de la m\u00e9moire (Herkenham et cols., 1991) (1), localis\u00e9s dans des zones en relations avec les fonctions cognitives, de la m\u00e9moire, l\u2019anxi\u00e9t\u00e9, la douleur, la perception sensorielle, la perception visc\u00e9rale, la coordination moteur et les fonctions endocrines. Ils se trouvent \u00e9galement en plus faible proportion dans le syst\u00e8me immunitaire, le syst\u00e8me nerveux p\u00e9riph\u00e9rique, les testicules, le c\u0153ur, l\u2019intestin gr\u00eale, la prostate, l\u2019ut\u00e9rus, la moelle osseuse et l\u2019endoth\u00e9lium vasculaire.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On peut observer une relation \u00e9troite entre la r\u00e9partition des r\u00e9cepteurs CB1 et&nbsp;<strong>les effets pharmacologiques produits par les cannabino\u00efdes<\/strong>. La grande pr\u00e9sence dans les ganglions basaux est corr\u00e9l\u00e9e par exemple avec les effets sur l\u2019activit\u00e9 locomotrice et la pr\u00e9sence dans les zones de l\u2019hippocampe et du cortex c\u00e9r\u00e9bral avec les effets sur la m\u00e9moire, l\u2019apprentissage et l\u2019effet anticonvulsif (Kantona y Freund, 2012&nbsp;; Lu et Mackie., 2016&nbsp;; Mechoulam, 2016&nbsp;; Macarrone et cols., 2015) (2).&nbsp;<strong>Les r\u00e9cepteurs CB1 sont les responsables de l\u2019effet psychoactif du cannabis.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-pullquote is-style-default\"><blockquote><p>\u00ab\u00a0Les premiers r\u00e9cepteurs d\u00e9crits \u00e9taient CB1 et CB2\u00a0\u00bb<\/p><cite>Dr. Mariano Garc\u00eda de Palau<\/cite><\/blockquote><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Les R\u00e9cepteurs Cannabinoides CB2<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Les r\u00e9cepteurs CB2<\/strong>&nbsp;se trouvent de mani\u00e8re pr\u00e9dominante dans les structures en relation avec le&nbsp;<strong>syst\u00e8me immunitaire&nbsp;<\/strong>: la Ligne Lympho\u00efde (lymphocytes B et T), la ligne my\u00e9lo\u00efde (monocytes, macrophages, granulocytes, mastocytes), les cellules gliales du SNC et de la rate (Galil\u00e8gue et cols. 1995) (6). En moindre proportion, ils sont pr\u00e9sents \u00e9galement dans les cellules d\u2019autres tissus et organes p\u00e9riph\u00e9riques comme le c\u0153ur, l\u2019endoth\u00e9lium, les os, le foie et le pancr\u00e9as. Dans le tissu nerveux, les niveaux de CB2 sont beaucoup plus bas que les niveaux de CB1. Les r\u00e9cepteurs CB2 du SNC sont pr\u00e9sents surtout dans les cellules gliales en augmentant su pr\u00e9sence significativement (environ 100 fois) dans les processus d\u2019inflammation ou apr\u00e8s une l\u00e9sion tissulaire (Benito et cols., 2008&nbsp;; Di Marzo et cols. 2015&nbsp;; Lu y Mackie., 2016) (7,8,9). On d\u00e9crit \u00e9galement sa pr\u00e9sence dans les cellules pro-g\u00e9nitrices neuronales et les neurones du cortex c\u00e9r\u00e9bral, l\u2019hippocampe, le globus pallidus, les zones limbiques et les zones m\u00e9senc\u00e9phaliques (Lanciego et cols 2011&nbsp;; Zhang et cols., 2016) (10). On pense que&nbsp;<strong>les r\u00e9cepteurs CB2 sont les responsables des propri\u00e9t\u00e9s immuno-modulatrices du cannabis<\/strong>. On n\u2019a pas observ\u00e9 que son activation produisait des effets psychoactifs (11).<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/def-hoja-1.jpg\" alt=\"\" class=\"wp-image-20465\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/def-hoja-1.jpg 600w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/def-hoja-1-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption>Cannabioides: una prometedora herramienta para el desarrollo de nuevas terapias<\/figcaption><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Les R\u00e9cepteurs 5-HT1A<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Les&nbsp;<strong>5-HT1A<\/strong>&nbsp;sont des&nbsp;<strong>r\u00e9cepteurs de S\u00e9rotonine<\/strong>&nbsp;pr\u00e9sents essentiellement dans les structures du syst\u00e8me nerveux central comme le cortex c\u00e9r\u00e9bral, l\u2019hippocampe, les amygdales et en moindre mesure dans les ganglions basaux et le thalamus (12,13, 14). Ces r\u00e9cepteurs provoquent diff\u00e9rentes cascades intracellulaires de messages chimiques qui peuvent produire une r\u00e9ponse tant excitante qu\u2019inhibante. Dans notre corps sont impliqu\u00e9s des processus comme l\u2019anxi\u00e9t\u00e9, l\u2019addiction, l\u2019app\u00e9tit, le sommeil, la perception de la douleur, les naus\u00e9es et vomissements entre autres.&nbsp;<strong>Le CBD, \u00e0 doses \u00e9lev\u00e9es<\/strong>, peut activer ces r\u00e9cepteurs en provoquant un effet&nbsp;<strong>anxiolytique<\/strong>&nbsp;(15,16,17),&nbsp;<strong>antid\u00e9pressif<\/strong>&nbsp;(17,18) et&nbsp;<strong>neuroprotecteur<\/strong>&nbsp;(19,20) entre autres.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Les R\u00e9cepteurs de type GPR55 et GPR119<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/efecto-sequito-effetdentourage-entourage-effect-Entourage-Effekt-effetto-seguito.jpg\" alt=\"\" class=\"wp-image-18186\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/efecto-sequito-effetdentourage-entourage-effect-Entourage-Effekt-effetto-seguito.jpg 600w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/efecto-sequito-effetdentourage-entourage-effect-Entourage-Effekt-effetto-seguito-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Les r\u00e9cepteurs du type GPR se situent dans les glandes surr\u00e9nales, la rate, le syst\u00e8me digestif et principalement dans le SNC&nbsp;: le noyau caud\u00e9 et le Putamen, l\u2019Hippocampe, le Thalamus, l\u2019Hypothalamus, le Cortex pr\u00e9frontal et le Cervelet.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Les GPR pourraient repr\u00e9senter un lien entre le syst\u00e8me immunitaire, le syst\u00e8me nerveux et le syst\u00e8me endocrine. En vue de ce lien, on peut imaginer des th\u00e9rapies futures dirig\u00e9es sur le m\u00e9tabolisme lipidique, l\u2019hom\u00e9ostasie du NA +\/K + ou d\u2019autres ions, ou la r\u00e9gulation des profils hormonaux. On a m\u00eame d\u00e9couvert une relation entre certains cannabinoides et l\u2019intol\u00e9rance aux glucides pour laquelle on avait recherch\u00e9 si ces r\u00e9cepteurs pouvaient servir \u00e0 traiter des syndromes relatifs au m\u00e9tabolisme \u00e9nerg\u00e9tique.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Le R\u00e9cepteur GPR55<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"viewer-7l2de\">Les r\u00e9cepteurs GPR55 se situent dans les r\u00e9gions du cerveau impliqu\u00e9s dans le contr\u00f4le des fonctions comme la m\u00e9moire, l\u2019apprentissage et la coordination motrice comme telles que le striatum dorsal, le noyau caud\u00e9 et le putamen, ainsi que divers tissus p\u00e9riph\u00e9riques incluant l\u2019il\u00e9on, les testicules la rate, les amygdales, les seins, le tissu adipeux \u00e9pilo\u00efque et m\u00eame dans certaines lignes des cellules endoth\u00e9liales (21,22). En raison de sa large distribution dans le SNC, on lui attribue diverses fonctions diverses qui varient selon la localisation du r\u00e9cepteur (23)&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Noyau Caud\u00e9<\/strong>&nbsp;\u2192 Inf\u00e9r\u00e9 par les neurones Dopaminergiques \/ fonctions d\u2019apprentissage et de m\u00e9moire \/ mouvement volontaire.<\/li><li><strong>Putamen Nucleus<\/strong>&nbsp;\u2192&nbsp;Fonctions li\u00e9es \u00e0 l\u2019apprentissage et au mouvement fin. Adiadococin\u00e9sie avec le cervelet<\/li><li><strong>Hippocampe<\/strong>&nbsp;\u2192 Inf\u00e9r\u00e9 par les neurones Dopaminergiques \/ fonctions d\u2019apprentissage et de m\u00e9moire \/ mouvement volontaire. M\u00e9moire en relation avec certains types\/ m\u00e9moire spatiale et orientation\/ gestion de l\u2019anxi\u00e9t\u00e9 \/ hyperactivit\u00e9.<\/li><li><strong>Thalamus<\/strong>&nbsp;\u2192 Filtre tous les stimuli sensoriels sauf l\u2019odorat \/ se connecte au lobe frontal, aux \u00e9motions, \u00e0 l\u2019hyperactivit\u00e9-d\u00e9pression\/ r\u00e9gule l\u2019activit\u00e9 visc\u00e9rale.<\/li><li><strong>Hypothalamus<\/strong>&nbsp;\u2192 R\u00e9gule la lib\u00e9ration d\u2019hormones dans l\u2019hypophyse \/ comportement alimentaire, apport liquidien, accouplement, agressivit\u00e9 \/ r\u00e9gulation visc\u00e9rale-endocrine automatique.<\/li><li><strong>Cervelet&nbsp;<\/strong>\u2192 Fonctions motrices, adiadococin\u00e9sie, \u00e9quilibre \/ fonctions cognitives, attention, langage, musique.<\/li><li><strong>Cortex pr\u00e9frontal&nbsp;<\/strong>\u2192&nbsp;Personnalisation de l\u2019individu, sentiments \/ comportement apathique, d\u00e9pression, processus d\u2019attention.<\/li><\/ul>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Il existe des preuves que le&nbsp;<strong>r\u00e9cepteur GPR55<\/strong>&nbsp;joue un r\u00f4le important dans la r\u00e9gulation du m\u00e9tabolisme osseux, dans le contr\u00f4le de la douleur inflammatoire, ainsi que dans la prolif\u00e9ration des cellules tumorales. Dans les tumeurs d\u2019origines diff\u00e9rentes, une expression significativement plus \u00e9lev\u00e9e a \u00e9t\u00e9 observ\u00e9e dans les tissus transform\u00e9s contre les tissus sains. De plus, cette expression \u00e9lev\u00e9e a \u00e9t\u00e9 corr\u00e9l\u00e9e avec une plus grande agressivit\u00e9 tumorale et un pronostique plus mauvais pour le patient (24) et est suppos\u00e9e favoriser la croissance, la migration et l\u2019invasion des cellules tumorales ainsi que la g\u00e9n\u00e9ration de m\u00e9tastases in vivo (21).<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Des \u00e9tudes r\u00e9centes lui attribuent \u00e9galement une&nbsp;<strong>possible implication dans le contr\u00f4le de la sensibilit\u00e9 \u00e0 la douleur.<\/strong>&nbsp;On a d\u00e9couvert que les souris d\u00e9pourvues de r\u00e9cepteur GPR55 -\/- ne pr\u00e9sentaient pas d\u2019hypersensibilit\u00e9 m\u00e9canique (hypersensibilit\u00e9 aux stimuli douloureux) chez les rongeurs tests pour la douleur inflammatoire et neuropathique (25).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Les liens avec lesquels nous pouvons agir sur ce r\u00e9cepteur sont le&nbsp;<a href=\"https:\/\/www.kalapa-clinic.com\/fr\/cannabidiol\/\">CBD<\/a>&nbsp;(antagoniste) et le&nbsp;<a href=\"https:\/\/www.kalapa-clinic.com\/fr\/tetrahidrocannabinol\/\">THC<\/a>&nbsp;(effet biphasique \u00e8 agoniste \u00e0 faible dose et antagoniste \u00e0 forte dose).<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-pullquote is-style-default\"><blockquote><p>\u00ab\u00a0Les r\u00e9cepteurs GPR55 ne se trouvent que chez les mammif\u00e8res, pas chez les oiseaux ou les poissons. Il s&rsquo;agit d&rsquo;un saut \u00e9volutif, d&rsquo;une adaptation suppl\u00e9mentaire \u00e0 la complexit\u00e9 des mammif\u00e8res, par rapport \u00e0 d&rsquo;autres esp\u00e8ces\u00a0\u00bb<\/p><cite>Dr. Mariano Garc\u00eda de Palau<\/cite><\/blockquote><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Les R\u00e9cepteurs GPR119<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Le r\u00e9cepteur GPR119<\/strong>&nbsp;d\u00e9montre un profil d\u2019expression relativement proche \u00e0 celui que l\u2019on trouve principalement dans les tissus pancr\u00e9atiques et intestinaux (26,27,28).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sa localisation dans les&nbsp;<strong>cellules \u03b2<\/strong>&nbsp;des \u00eelots pancr\u00e9atiques et des&nbsp;<strong>cellules L<\/strong>&nbsp;intestinales ent\u00e9rococciques attire l\u2019attention sur l\u2019implication possible des GPR119 dans&nbsp;<strong>le contr\u00f4le de l\u2019hom\u00e9ostasie du glucose<\/strong>&nbsp;(29) et de l<strong>\u2019ob\u00e9sit\u00e9<\/strong>&nbsp;(30).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;Le GPR119&nbsp;et le traitement pour l\u2019ob\u00e9sit\u00e9<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Des \u00e9tudes in vitro avec des mod\u00e8les animaux ont d\u00e9montr\u00e9 que sa modulation produisait des effets b\u00e9n\u00e9fiques sur l\u2019hom\u00e9ostasie du glucose, en r\u00e9duisant l\u2019apport des aliments (et par cons\u00e9quent limitant la prise de poids) et pourrait possiblement aider \u00e0 pr\u00e9server les cellules b\u00e9ta-\u03b2 qui produisent de l\u2019insuline dans les \u00eelots pancr\u00e9atiques (31).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Le GPR119&nbsp;et l\u2019hom\u00e9ostasie du glucose<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">L\u2019expression du GPR119 dans les cellules \u03b2 des \u00eelots pancr\u00e9atiques a conduit \u00e0&nbsp;<strong>l\u2019hypoth\u00e8se<\/strong>&nbsp;que ce r\u00e9cepteur jouait un r\u00f4le important dans&nbsp;<strong>la modulation de la s\u00e9cr\u00e9tion d\u2019insuline<\/strong>. Dans des \u00e9tudes avec des animaux, on a observ\u00e9 que la stimulation du GPR119 exer\u00e7ait un double effet sur la r\u00e9duction de glucose dans le sang, agissant directement sur la cellule \u03b2 pancr\u00e9atique favorisant la lib\u00e9ration d\u2019insuline, et indirectement par les cellules ent\u00e9ro-endocrines lib\u00e9rant des incr\u00e9tines telles que GLP-1 (peptide de type glucagon) ou d\u2019autres agents anti-hyperglyc\u00e9miques (32, 33, 34).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Le GPR119&nbsp;et ses possibles applications dans la d\u00e9couverte de nouveaux traitements<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Les donn\u00e9es disponibles actuellement sur les effets des agonistes GPR119 sur mod\u00e8les animaux indiquent qu\u2019ils pourraient \u00eatre&nbsp;<strong>des agents importants pour le traitement du diab\u00e8te de type 2 et<\/strong>&nbsp;l\u2019ob\u00e9sit\u00e9. La lib\u00e9ration de GPL-1 gr\u00e2ce \u00e0 la stimulation du GPR119 am\u00e9liore l\u2019hom\u00e9ostasie du glucose, en limitant en m\u00eame temps l\u2019ingestion d\u2019aliments et la prise de poids (35,36,37).<\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">Les R\u00e9cepteurs vanillo\u00efdes \u00e0 potentiel transitoire ou TRPV<\/h2>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Il s\u2019agit d\u2019une famille de canaux ioniques qui modulent le flux d\u2019ions \u00e0 travers la membrane cellulaire, en influant de cette mani\u00e8re la conductance de l\u2019influx nerveux et la transmission, la modulation et l\u2019int\u00e9gration des stimuli nocifs (38). Les&nbsp;<strong>TRPV<\/strong>&nbsp;chez les mammif\u00e8res sont form\u00e9s par 6 membres r\u00e9partis e 2 groupes selon le degr\u00e9 d\u2019homologie, TRPV 1-4 et TRPV 5-6, et sont impliqu\u00e9s dans la reconnaissance des stimuli thermiques et nociceptifs, et dans les m\u00e9canismes modulant l\u2019inflammation locale (39, 44, 45).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Son mode de distribution tissulaire est tr\u00e8s large, \u00e9tant pr\u00e9sent dans&nbsp;<strong>pratiquement tous les tissus<\/strong>, en particulier dans le SNC et p\u00e9riph\u00e9rique.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Son mode de distribution tissulaire est tr\u00e8s large, \u00e9tant pr\u00e9sent dans&nbsp;<strong>pratiquement tous les tissus<\/strong>, en particulier dans le SNC et p\u00e9riph\u00e9rique. Ils interviennent dans une grande vari\u00e9t\u00e9 de fonctions cellulaires telles que l\u2019initiation de la douleur, la thermor\u00e9gulation, la s\u00e9cr\u00e9tion salivaire, l\u2019inflammation, le tonus musculaire lisse et l\u2019hom\u00e9ostasie du calcium et du magn\u00e9sium, entre autres (47). Le fait que sa fonction de canal ionique soit renforc\u00e9e par des m\u00e9diateurs pro-inflammatoires lib\u00e9r\u00e9s lors de l\u00e9sions tissulaires, ainsi que sa large distribution dans diff\u00e9rents tissus, attribuent \u00e0 ces r\u00e9cepteurs un r\u00f4le important dans la modulation des processus de sensibilisation inflammatoire des nocicepteurs qui provoquent une hyperalg\u00e9sie dans la zone endommag\u00e9e (40, 41, 42, 43).&nbsp;<strong>Actuellement, nous \u00e9tudions ces r\u00e9cepteurs et leur interaction avec le SEC afin de d\u00e9velopper de nouvelles cibles th\u00e9rapeutiques visant le traitement analg\u00e9sique.<\/strong><\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Bibliographie sur les r\u00e9cepteurs cannabino\u00efdes<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">[1] Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR y Rice KC (1991).&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1992016\" target=\"_blank\" rel=\"noreferrer noopener\">Characterization and localization of cannabinoid receptors in the rat brain: A quantitative in vitro autoradiographic study<\/a>.&nbsp;<em>J Neurosci<\/em>;&nbsp;<strong>11<\/strong>:563-83.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[2] Katona I, Freund TF.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22524785\" target=\"_blank\" rel=\"noreferrer noopener\">Multiple functions of endocannabinoid signaling in the brain<\/a>. Annu Rev Neurosci. 2012, 35:529-558<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[3] Lu HC, Mackie K.&nbsp;<em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26698193\" target=\"_blank\" rel=\"noreferrer noopener\">An introduction to the endogenous cannabinoid system<\/a><\/em>. Biol Psychiatry. 2016, 79(7):516-525.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[4] Mechoulam R.&nbsp;<em><a href=\"http:\/\/europepmc.org\/abstract\/med\/26426888\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabis \u2013 the Israeli perspective<\/a><\/em>. J Basic Clin Physiol Pharmacol. 2016, 27(3):181-187.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[5] Macarrone M, Bab I, Bir\u00f3 T, Cabral GA&nbsp;<em>y cols<\/em>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4420685\/\" target=\"_blank\" rel=\"noreferrer noopener\">Endocannabinoid signaling at the periphery: 50 years after THC<\/a>. Trends Pharmacol Sci. 2015, 36(5):277-296.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[6] Gali\u00e8gue S, Mary S, Marchand J, Dussossoy D&nbsp;<em>y cols.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7556170\" target=\"_blank\" rel=\"noreferrer noopener\">Expression of central and peripheral cannabinoid receptors in human im- mune tissues and leukocyte subpopulations.<\/a><\/em>&nbsp;Eur J Biochem. 1995, 232(1):54-61.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[7] Benito C, Tol\u00f3n RM, Pazos MR, N\u00fa\u00f1ez E&nbsp;<em>y cols<\/em>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2219537\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabinoid CB2 re- ceptors in human brain inflammation<\/a>. Br J Pharmacol. 2008, 153(2):277-285.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[8] Di Marzo V, Pisticelli F.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4604172\/\" target=\"_blank\" rel=\"noreferrer noopener\">The endocannabinoid system and its modulation by phytocannabinoids. Neurotherapeutics<\/a>. 2015, 12(4):692-698.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[9] Lu HC, Mackie K.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26698193\" target=\"_blank\" rel=\"noreferrer noopener\">An introduction to the endogenous cannabinoid system<\/a>. Biol Psychiatry. 2016, 79(7):516-525.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[10] Lanciego JL, Barroso-Chinea P, Rico AJ, Conte-Perales L&nbsp;<em>y cols.&nbsp;<\/em><a href=\"http:\/\/journals.sagepub.com\/doi\/abs\/10.1177\/0269881110367732?journalCode=jopa\" target=\"_blank\" rel=\"noreferrer noopener\">Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis<\/a>. J Psychopharmacol. 2011, 25(1):97-104.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[11] Zhang HY, Gao M, Shen H, Bi GH&nbsp;<em>y cols.&nbsp;<\/em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26833913\" target=\"_blank\" rel=\"noreferrer noopener\">Expression of functional cannabinoid CB2 receptor in VTA dopamine neurons in rats<\/a>. Addict Biol. 2016. doi: 10.1111\/adb.12367.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[12] &nbsp;Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden ( 1999)&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9935065\" target=\"_blank\" rel=\"noreferrer noopener\">Localization of 5-HT1A receptors in the living human brain using [carbonyl-11C]WAY-100635: PET with anatomic standardization technique<\/a>.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9935065\" target=\"_blank\" rel=\"noreferrer noopener\">J Nucl Med.<\/a>&nbsp;1999 Jan;40(1):102-9.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[13] Richard A. Glennon, Malgorzata Dukat and Richard B. Westkaemper<a href=\"http:\/\/www.acnp.org\/g4\/GN401000039\/Ch039.html\" target=\"_blank\" rel=\"noreferrer noopener\">.&nbsp; Serotonin Receptor Subtypes and Ligands<\/a>. American College of Neuropsychoparmacology.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[14] Departament de Neuroquimica i Neurofarmacologia, Institut d\u2019Investigacions Biom\u00e8diques de Barcelona (CSIC), IDIBAPS, Barcelona, Spain.&nbsp;&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18761712\" target=\"_blank\" rel=\"noreferrer noopener\">Serotonin 1A receptors in human and monkey prefrontal cortex are mainly expressed in pyramidal neurons and in a GABAergic interneuron subpopulation: implications for schizophrenia and its treatment.<\/a>&nbsp;&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18761712\" target=\"_blank\" rel=\"noreferrer noopener\">J Neurochem.<\/a>&nbsp;2008 Oct;107(2):488-96. doi: 10.1111\/j.1471-4159.2008.05649.x. Epub 2008 Sep 16.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[15] de Mello Schier AR, de Oliveira Ribeiro NP, Coutinho DS, Machado S, Arias-Carri\u00f3n O, Crippa JA, Zuardi AW, Nardi AE, Silva AC1.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24923339\" target=\"_blank\" rel=\"noreferrer noopener\">Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa<\/a>. CNS Neurol Disord Drug Targets. 2014;13(6):953-60.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[16] Leonardo BM Resstel,1 Rodrigo F Tavares,1,* Sabrina FS Lisboa,1,* S\u00e2mia RL Joca,2 Fernando MA Corr\u00eaa,1 and Francisco S Guimar\u00e3es1.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2697769\/\" target=\"_blank\" rel=\"noreferrer noopener\">5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats<\/a>. Br J Pharmacol. 2009 Jan; 156(1): 181\u2013188.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[17] TV Zanelati,* C Biojone,* FA Moreira, FS Guimar\u00e3es and SRL Joca<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2823358\/\" target=\"_blank\" rel=\"noreferrer noopener\">. Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors<\/a>. Br J Pharmacol. 2010 Jan; 159(1): 122\u2013128.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[18] Campos AC1, Guimar\u00e3es FS<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18446323\" target=\"_blank\" rel=\"noreferrer noopener\">. Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology (Berl)<\/a>. 2008 Aug;199(2):223-30. doi: 10.1007\/s00213-008-1168-x. Epub 2008 May 1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[19] Mishima K, Hayakawa K, Abe K, Ikeda T, Egashira N, Iwasaki K, Fujiwara M.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15845890\" target=\"_blank\" rel=\"noreferrer noopener\">Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism<\/a>. Stroke. 2005 May;36(5):1077-82. Epub 2005 Apr 21.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[20] Hayakawa K1, Mishima K, Nozako M, Ogata A, Hazekawa M, Liu AX, Fujioka M, Abe K, Hasebe N, Egashira N, Iwasaki K, Fujiwara M.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17320118\" target=\"_blank\" rel=\"noreferrer noopener\">Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance<\/a>. Neuropharmacology. 2007 Mar;52(4):1079-87. Epub 2007 Feb 21.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[21]- Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH&nbsp;<em>et al<\/em>. (1999). Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.&nbsp;<em>Brain Res Mol Brain Res<\/em>&nbsp;<strong>64<\/strong>: 193\u2013198.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[22]- Ryberg E, Larsson N, Sjogren S, Hjorth S, Hermansson NO, Leonova J&nbsp;<em>et al<\/em>. (2007). The orphan receptor GPR55 is a novel cannabinoid receptor.&nbsp;<em>Br J Pharmacol<\/em>&nbsp;<strong>152<\/strong>: 1092\u20131101.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[23]- Marichal-Cancino BA, Fajardo-Valdez A, Ruiz-Contreras AE, Mendez-Diaz M, Prospero-Garcia O. Advances in the physiology of GPR55 in the central nervous system. Curr Neuropharmacol. 2016.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[24]- E P\u00e9rez-G\u00f3mez,&nbsp;C Andradas,&nbsp;J M Flores,&nbsp;M Quintanilla,&nbsp;J M Paramio,&nbsp;M Guzm\u00e1n&nbsp;and&nbsp;C S\u00e1nchez<em>Oncogene<\/em>&nbsp;<strong>32<\/strong>, 2534-2542 (16 May 2013).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[25]- Staton PC, Hatcher JP, Walker DJ, et al. The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain.&nbsp;Pain.&nbsp;2008;139(1):225\u2013236.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[26]- Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C (Mar 2006). \u00ab&nbsp;Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents&nbsp;\u00bb.&nbsp;<em>Cell Metabolism<\/em>.&nbsp;<strong>3<\/strong>&nbsp;(3): 167\u201375.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[27] \u2013 A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release.<em>Chu ZL, Jones RM, He H, Carroll C, Gutierrez V, Lucman A, Moloney M, Gao H, Mondala H, Bagnol D, Unett D, Liang Y, Demarest K, Semple G, Behan DP, Leonard J<\/em>&nbsp;<em>Endocrinology. 2007 Jun; 148(6):2601-9.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[28]-. Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor.&nbsp;<em>Soga T, Ohishi T, Matsui T, Saito T, Matsumoto M, Takasaki J, Matsumoto S, Kamohara M, Hiyama H, Yoshida S, Momose K, Ueda Y, Matsushime H, Kobori M, Furuichi K<\/em>&nbsp;Biochem Biophys Res Commun. 2005 Jan 28; 326(4):744-51.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[29] -N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119<strong>.&nbsp;<\/strong>Zhi-Liang Chu&nbsp;Chris Carroll&nbsp;Ruoping Chen&nbsp;Jean Alfonso&nbsp;Veronica GutierrezHongmei He&nbsp;Annette Lucman&nbsp;Charles Xing&nbsp;Kristen Sebring&nbsp;Jinyao Zhou&nbsp;<em>Molecular Endocrinology<\/em>, Volume 24, Issue 1, 1 January 2010, Pages 161\u2013170.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[30]- Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.&nbsp;<em>Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C<\/em>&nbsp;Cell Metab. 2006 Mar; 3(3):167-75.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[31] 24-Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.&nbsp;J Biol Chem.&nbsp;2003;278:471\u2013478.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[32] Upregulated insulin secretion in insulin-resistant mice: evidence of increased islet GLP1 receptor levels and GPR119-activated GLP1 secretion. Ahlkvist L,&nbsp;Brown K,&nbsp;Ahr\u00e9n B. Endocr Connect.&nbsp; 2013 Mar 18;2(2):69-78. Print 2013 Jun 1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[33] Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes. Nauck MA,&nbsp;Baller B,&nbsp;Meier JJ. Diabetes.&nbsp; 2004 Dec;53 Suppl 3:S190-6.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[34] Gromada J,&nbsp;Brock B,&nbsp;Schmitz O,&nbsp;Rorsman P(2004).&nbsp;Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.&nbsp;<em>Basic Clin Pharmacol Toxicol<\/em>&nbsp;<strong>95<\/strong>:&nbsp;252\u2013262.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[35] The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion. Patrick E. MacDonald<strong>,&nbsp;<\/strong>Wasim El-kholy<strong>,&nbsp;<\/strong>Michael J. Riedel<strong>,&nbsp;<\/strong>Anne Marie F. Salapatek<strong>,&nbsp;<\/strong>Peter E. Light<strong>,&nbsp;<\/strong>Michael B. Wheeler. Diabetes&nbsp;2002 Dec;&nbsp;51(suppl 3):&nbsp;S434-S442.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[36] Drucker DJ&nbsp;(2006).&nbsp;The biology of incretin hormones.&nbsp;<em>Cell Metab<\/em>&nbsp;<strong>3<\/strong>:&nbsp;153\u2013165.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[37] Holst JJ&nbsp;(2006).&nbsp;Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005.&nbsp;<em>Diabetologia<\/em>&nbsp;<strong>49<\/strong>:&nbsp;253\u2013260.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[38] VENKATACHALAN, K. Y MONTELL, C. (2007) TRPchannels. Annu. Rev. Biochem. 76: 387-417.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[39] CATERINA, M.J. Y JULIUS, D.D. (2001) The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci. 24: 487-517.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[40] Impaired nociception and pain sensation in mice lacking the capsaicin receptor.&nbsp;<em>Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D<\/em>&nbsp;<em>Science. 2000 Apr 14; 288(5464):306-13.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[41] BELMONTE, C. Y VIANA, F. (2008) Molecular and cellular limits to somatosensory specificity. Mol. Pain. 4: 14.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[42] Cui M, Honore P, Zhong C, Gauvin D, Mikusa J, Hernandez G, Chandran P, Gomtsyan A, Brown B, Bayburt EK, Marsh K, Bianchi B, McDonald H, Niforatos W, Neelands TR, Moreland RB, Decker MW, Lee CH, Sullivan JP, Faltynek CR (2006). \u00ab&nbsp;TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists&nbsp;\u00bb.&nbsp;<em>J. Neurosci<\/em>.&nbsp;26&nbsp;(37): 9385\u201393.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[43] Cellular mechanisms of neurogenic inflammation.<em>Richardson JD, Vasko MR<\/em>&nbsp;<em>J Pharmacol Exp Ther. 2002 Sep; 302(3):839-45.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[44] &nbsp;The capsaicin receptor: a heat-activated ion channel in the pain pathway.&nbsp;<em>Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D<\/em>&nbsp;<em>Nature. 1997 Oct 23; 389(6653):816-24.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[45]- Kym PR, Kort ME, Hutchins CW: Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009, 78: 211-216. 10.1016\/j.bcp.2009.02.014<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[46] Nilius B, OwsianikG. The transient receptor potential family of ion channels. Genome Biol. 2011;12(3):218.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[47] Canales i\u00f3nicos Receptores de Potencial Transitorio y su papel protag\u00f3nico en la terapia analg\u00e9sica. DraC. Loipa Gal\u00e1n Mart\u00ednez,<sup>I&nbsp;<\/sup>MSc. Rafael Dami\u00e1n Souto C\u00e1rdenas,<sup>II&nbsp;<\/sup>DraC. Suria Vald\u00e9s Garc\u00eda,&nbsp;<sup>III&nbsp;<\/sup>Dr. Enrique Minaberriet Conceiro<sup>III<\/sup>Rev Cubana de Investigaciones Biom\u00e9dicas. 2015;34(3).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[48]-BELMONTE, C. Y VIANA, F. (2008) Molecular and cellular limits to somatosensory specificity. Mol. Pain. 4: 14.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-container gb-block-container\"><div class=\"gb-container-inside\"><div class=\"gb-container-content\"><\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-group librarytreatments\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<p class=\"wp-block-paragraph\" id=\"viewer-edlla\"><\/p>\n<\/div><\/div>\n\n\n<div class=\"container genesis-custom-block \">\n\t<div class=\"row\">\n     <div class=\"col-12 text-center\">\n        <h2 class=\"sec-title wow fadeInUp introtitle\" style=\"visibility: visible; animation-name: fadeInUp;\">\n              <span><\/span>\n         <\/h2>\n         <div class=\"introsubtitle sec-title\">Vous voulez en savoir plus sur les r\u00e9cepteurs des cannabino\u00efdes ?<\/div>\n              <p class=\"wow fadeInUp introdescription\" style=\"visibility: visible; animation-name: fadeInUp;\">\n                            Une \u00e9quipe de sp\u00e9cialistes se tient \u00e0 votre disposition pour r\u00e9pondre \u00e0 vos questions              <\/p>\n         <\/div>\n     <\/div>\n<\/div>\n\n\n\n\n<div style=\"display: none;\" id=\"treatment_popup_form\">\n\t<div class=\"container\">\n    \t<div class=\"row\">\n        \t<div class=\"col-lg-12\">\n\t\t\t\t<h2>Recevoir plus d&rsquo;informations<\/h2>\n\t\t\t\t<p>Laissez vos coordonn\u00e9es ci-dessous et nous vous enverrons des informations sur R\u00e9cepteurs cannabino\u00efdes.<\/p>\n\t\t\t<\/div>\n\t\t\t<!--<div class=\"col-lg-4\">\n\t\t\t\t<div class=\"f-logo\">\n\t\t\t\t\t<img decoding=\"async\" src=\"\/wp-content\/themes\/understrap\/assets\/images\/logo_kalapa_clinic_retina.png.webp\" alt=\"\">\n                <\/div>\n\t\t\t<\/div>-->\n\t\t<\/div>\n\t<\/div>\t\n\t<div role=\"form\" class=\"wpcf7\" id=\"wpcf7-f54320-o2\" lang=\"fr-FR\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/fr\/wp-json\/wp\/v2\/pages\/54261#wpcf7-f54320-o2\" method=\"post\" class=\"wpcf7-form init\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"54320\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"5.5.6\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"fr_FR\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f54320-o2\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<\/div>\n<p><label> Nom et Pr\u00e9nom *<br \/>\n<span class=\"wpcf7-form-control-wrap your-name\"><input type=\"text\" name=\"your-name\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" \/><\/span> <\/label><\/p>\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\">\n<label style=\"color: #748494;\"> Votre adresse email *<br \/>\n    <span class=\"wpcf7-form-control-wrap your-email\"><input type=\"email\" name=\"your-email\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" \/><\/span><\/label>\n   <\/div>\n<div class=\"wp-block-column\">\n<label style=\"color: #748494;\"> Telephone<br \/>\n<span class=\"wpcf7-form-control-wrap phonetext-56\"><input type=\"text\" name=\"phonetext-56\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-phonetext\" aria-invalid=\"false\" \/><input type=\"hidden\" name=\"phonetext-56-country-code\" class=\"wpcf7-phonetext-country-code\" \/><\/span><\/label>\n   <\/div>\n<\/div>\n<p><label> Pays de r\u00e9sidence<br \/>\n<span class=\"wpcf7-form-control-wrap countrytext-664\"><input type=\"text\" name=\"countrytext-664\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-countrytext\" aria-invalid=\"false\" \/><\/span><\/label><br \/>\n<label> Maladie*<br \/>\n<span class=\"wpcf7-form-control-wrap Maladie\"><input type=\"text\" name=\"Maladie\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" \/><\/span><\/label><br \/>\n<label> Message<br \/>\n<span class=\"wpcf7-form-control-wrap your-message\"><textarea name=\"your-message\" cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\"><\/textarea><\/span><\/label><\/p>\n<p><span class=\"wpcf7-form-control-wrap acceptance-LOPD\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><input type=\"checkbox\" name=\"acceptance-LOPD\" value=\"1\" aria-invalid=\"false\" \/><\/span><\/span><\/span>  Oui, j'accepte la <a style=\"color:#4da8ca;text-decoration:underline;\" href=\"\/fr\/politique-de-confidentialite\/\">politique de confidentilit\u00e9.<\/a> de Kalapa Clinic.<\/p>\n<p><input type=\"submit\" value=\"ENVOYER\" class=\"wpcf7-form-control has-spinner wpcf7-submit btn btn-orange sndbtntreatment\" \/><\/p>\n<p><FONT SIZE=2>Kalapa Clinic vous informe que les donn\u00e9es \u00e0 caract\u00e8re personnel indiqu\u00e9es en compl\u00e9tant ce formulaire seront trait\u00e9es par Grupo HS3 Project Development, S.L. en tant que responsable du site web. La finalit\u00e9 de la collecte et du traitement des informations personnelles que vous nous envoyez est de pouvoir vous informez sur les services que nous offrons sur les traitements \u00e0 base de cannabino\u00efdes. La l\u00e9gitimit\u00e9 se r\u00e9alise \u00e0 travers votre consentement. Nous vous informons que les donn\u00e9es que vous nous confiez seront conserv\u00e9es sur des serveurs situ\u00e9s en Union Europ\u00e9enne. Vous pourrez exercer vos droits d'acc\u00e8s, de modification, de limitation et de suppression de vos donn\u00e9es \u00e0 n'importe quel moment. Vous pouvez consulter toutes les informations additionnelles et d\u00e9taill\u00e9es sur la protection des donn\u00e9es personnelles sur notre site web <a href=\"\/fr\/politique-de-confidentialite\/\">pol\u00edtica de privacidad.<\/a>. <\/FONT><\/p>\n<p style=\"display: none !important;\"><label>&#916;<textarea name=\"_wpcf7_ak_hp_textarea\" cols=\"45\" rows=\"8\" maxlength=\"100\"><\/textarea><\/label><input type=\"hidden\" id=\"ak_js_2\" name=\"_wpcf7_ak_js\" value=\"105\"\/><script>document.getElementById( \"ak_js_2\" ).setAttribute( \"value\", ( new Date() ).getTime() );<\/script><\/p><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div><div data-component=\"cf7rs-success\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Merci!&lt;\/h3&gt;\r\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\r\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"6000\" data-placement=\"in-modal\" ><\/div><div data-component=\"cf7rs-error\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Erreur d\u00e9tect\u00e9e!&lt;\/h3&gt;\r\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\r\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"6000\" data-placement=\"in-modal\" ><\/div><\/form><\/div>\t<\/div>\n\n\n\n<div class=\"row justify-content-center\">\n\t<div class=\"col-lg-8 text-center  wow fadeInUp\" style=\"visibility: visible; animation-name: fadeInUp;\">\n\t\t<a data-fancybox data-src=\"#treatment_popup_form\" href=\"javascript:;\" class=\"btn btn-grad btn-lg btn-round\">Demander plus d&rsquo;informations<\/a>\n\t<\/div>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Les R\u00e9cepteurs Cannabino\u00efdes Infographie des r\u00e9cepteurs cannabino\u00efdes R\u00e9cepteurs cannabino\u00efdes d\u00e9couverts jusqu&rsquo;\u00e0 pr\u00e9sent Ce n\u2019est qu\u2019en 1988, gr\u00e2ce \u00e0 des exp\u00e9riences utilisant le CP55940 radio-marqu\u00e9, que le premier de ces r\u00e9cepteurs fut finalement identifi\u00e9 (1). Ce r\u00e9cepteur appel\u00e9&nbsp;cannabino\u00efde 1 (CB1),&nbsp;se trouve principalement dans le&nbsp;Syst\u00e8me Nerveux Central (CNS)&nbsp;et les organes p\u00e9riph\u00e9riques (2). Le second r\u00e9cepteur cannabino\u00efde (CB2)&nbsp;fut [&#8230;]<\/p>\n<p><a class=\"understrap-read-more-link\" href=\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/\">En savoir plus \u2192<\/a><\/p>\n","protected":false},"author":20,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/containerpage.php","meta":{"inline_featured_image":false,"_uag_custom_page_level_css":"","footnotes":""},"class_list":["post-54261","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>R\u00e9cepteurs cannabino\u00efdes et cannabis m\u00e9dicinal | Kalapa Clinic<\/title>\n<meta name=\"description\" content=\"Les principaux r\u00e9cepteurs du syst\u00e8me endocannabino\u00efde sont les r\u00e9cepteurs CB1 et CBD2. Mais il existe d&#039;autres r\u00e9cepteurs tels que le GPR55 ou le 5-HT1A qui ont des fonctions importantes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"R\u00e9cepteurs cannabino\u00efdes et cannabis m\u00e9dicinal | Kalapa Clinic\" \/>\n<meta property=\"og:description\" content=\"Les principaux r\u00e9cepteurs du syst\u00e8me endocannabino\u00efde sont les r\u00e9cepteurs CB1 et CBD2. Mais il existe d&#039;autres r\u00e9cepteurs tels que le GPR55 ou le 5-HT1A qui ont des fonctions importantes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/\" \/>\n<meta property=\"og:site_name\" content=\"Kalapa Clinic\" \/>\n<meta property=\"article:modified_time\" content=\"2021-01-19T15:24:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-1024x723.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"20 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/#organization\",\"name\":\"Kalapa Clinic\",\"url\":\"https:\/\/www.kalapa-clinic.com\/fr\/\",\"sameAs\":[],\"logo\":{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/#logo\",\"inLanguage\":\"fr-FR\",\"url\":\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/Logo-Kalapa-Clinic.jpg\",\"contentUrl\":\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/Logo-Kalapa-Clinic.jpg\",\"width\":500,\"height\":500,\"caption\":\"Kalapa Clinic\"},\"image\":{\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/#logo\"}},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/#website\",\"url\":\"https:\/\/www.kalapa-clinic.com\/fr\/\",\"name\":\"Kalapa Clinic\",\"description\":\"Informaci\u00f3n sobre Cannabis Medicinal\",\"publisher\":{\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.kalapa-clinic.com\/fr\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#primaryimage\",\"inLanguage\":\"fr-FR\",\"url\":\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK.jpg\",\"contentUrl\":\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK.jpg\",\"width\":1192,\"height\":842,\"caption\":\"Infografia Cannabidiol propiedades terapeuticas | Kalapa Clinic\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#webpage\",\"url\":\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/\",\"name\":\"R\u00e9cepteurs cannabino\u00efdes et cannabis m\u00e9dicinal | Kalapa Clinic\",\"isPartOf\":{\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#primaryimage\"},\"datePublished\":\"2020-11-30T12:06:26+00:00\",\"dateModified\":\"2021-01-19T15:24:10+00:00\",\"description\":\"Les principaux r\u00e9cepteurs du syst\u00e8me endocannabino\u00efde sont les r\u00e9cepteurs CB1 et CBD2. Mais il existe d'autres r\u00e9cepteurs tels que le GPR55 ou le 5-HT1A qui ont des fonctions importantes.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/www.kalapa-clinic.com\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"R\u00e9cepteurs cannabino\u00efdes\"}]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"R\u00e9cepteurs cannabino\u00efdes et cannabis m\u00e9dicinal | Kalapa Clinic","description":"Les principaux r\u00e9cepteurs du syst\u00e8me endocannabino\u00efde sont les r\u00e9cepteurs CB1 et CBD2. Mais il existe d'autres r\u00e9cepteurs tels que le GPR55 ou le 5-HT1A qui ont des fonctions importantes.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/","og_locale":"fr_FR","og_type":"article","og_title":"R\u00e9cepteurs cannabino\u00efdes et cannabis m\u00e9dicinal | Kalapa Clinic","og_description":"Les principaux r\u00e9cepteurs du syst\u00e8me endocannabino\u00efde sont les r\u00e9cepteurs CB1 et CBD2. Mais il existe d'autres r\u00e9cepteurs tels que le GPR55 ou le 5-HT1A qui ont des fonctions importantes.","og_url":"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/","og_site_name":"Kalapa Clinic","article_modified_time":"2021-01-19T15:24:10+00:00","og_image":[{"url":"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-1024x723.jpg"}],"twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"20 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Organization","@id":"https:\/\/www.kalapa-clinic.com\/fr\/#organization","name":"Kalapa Clinic","url":"https:\/\/www.kalapa-clinic.com\/fr\/","sameAs":[],"logo":{"@type":"ImageObject","@id":"https:\/\/www.kalapa-clinic.com\/fr\/#logo","inLanguage":"fr-FR","url":"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/Logo-Kalapa-Clinic.jpg","contentUrl":"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/Logo-Kalapa-Clinic.jpg","width":500,"height":500,"caption":"Kalapa Clinic"},"image":{"@id":"https:\/\/www.kalapa-clinic.com\/fr\/#logo"}},{"@type":"WebSite","@id":"https:\/\/www.kalapa-clinic.com\/fr\/#website","url":"https:\/\/www.kalapa-clinic.com\/fr\/","name":"Kalapa Clinic","description":"Informaci\u00f3n sobre Cannabis Medicinal","publisher":{"@id":"https:\/\/www.kalapa-clinic.com\/fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.kalapa-clinic.com\/fr\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"ImageObject","@id":"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#primaryimage","inLanguage":"fr-FR","url":"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK.jpg","contentUrl":"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK.jpg","width":1192,"height":842,"caption":"Infografia Cannabidiol propiedades terapeuticas | Kalapa Clinic"},{"@type":"WebPage","@id":"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#webpage","url":"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/","name":"R\u00e9cepteurs cannabino\u00efdes et cannabis m\u00e9dicinal | Kalapa Clinic","isPartOf":{"@id":"https:\/\/www.kalapa-clinic.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#primaryimage"},"datePublished":"2020-11-30T12:06:26+00:00","dateModified":"2021-01-19T15:24:10+00:00","description":"Les principaux r\u00e9cepteurs du syst\u00e8me endocannabino\u00efde sont les r\u00e9cepteurs CB1 et CBD2. Mais il existe d'autres r\u00e9cepteurs tels que le GPR55 ou le 5-HT1A qui ont des fonctions importantes.","breadcrumb":{"@id":"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.kalapa-clinic.com\/fr\/recepteurs-cannabinoides\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.kalapa-clinic.com\/fr\/"},{"@type":"ListItem","position":2,"name":"R\u00e9cepteurs cannabino\u00efdes"}]}]}},"featured_image_src":null,"featured_image_src_square":null,"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"gb-block-post-grid-landscape":false,"gb-block-post-grid-square":false},"uagb_author_info":{"display_name":"emarketing","author_link":"https:\/\/www.kalapa-clinic.com\/fr\/author\/emarketing\/"},"uagb_comment_info":0,"uagb_excerpt":"Les R\u00e9cepteurs Cannabino\u00efdes Infographie des r\u00e9cepteurs cannabino\u00efdes R\u00e9cepteurs cannabino\u00efdes d\u00e9couverts jusqu&rsquo;\u00e0 pr\u00e9sent Ce n\u2019est qu\u2019en 1988, gr\u00e2ce \u00e0 des exp\u00e9riences utilisant le CP55940 radio-marqu\u00e9, que le premier de ces r\u00e9cepteurs fut finalement identifi\u00e9 (1). Ce r\u00e9cepteur appel\u00e9&nbsp;cannabino\u00efde 1 (CB1),&nbsp;se trouve principalement dans le&nbsp;Syst\u00e8me Nerveux Central (CNS)&nbsp;et les organes p\u00e9riph\u00e9riques (2). Le second r\u00e9cepteur cannabino\u00efde (CB2)&nbsp;fut\u2026","_links":{"self":[{"href":"https:\/\/www.kalapa-clinic.com\/fr\/wp-json\/wp\/v2\/pages\/54261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kalapa-clinic.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kalapa-clinic.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kalapa-clinic.com\/fr\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kalapa-clinic.com\/fr\/wp-json\/wp\/v2\/comments?post=54261"}],"version-history":[{"count":10,"href":"https:\/\/www.kalapa-clinic.com\/fr\/wp-json\/wp\/v2\/pages\/54261\/revisions"}],"predecessor-version":[{"id":61536,"href":"https:\/\/www.kalapa-clinic.com\/fr\/wp-json\/wp\/v2\/pages\/54261\/revisions\/61536"}],"wp:attachment":[{"href":"https:\/\/www.kalapa-clinic.com\/fr\/wp-json\/wp\/v2\/media?parent=54261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}