{"id":54143,"date":"2020-11-25T17:40:56","date_gmt":"2020-11-25T17:40:56","guid":{"rendered":"https:\/\/kc.multimarketing.dev\/cannabidiol\/"},"modified":"2020-12-16T11:55:21","modified_gmt":"2020-12-16T11:55:21","slug":"cannabidiol-cannabis-oil","status":"publish","type":"page","link":"https:\/\/www.kalapa-clinic.com\/en\/cannabidiol-cannabis-oil\/","title":{"rendered":"Cannabidiol"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cannabidiol (CBD)<\/h2>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-1 one-column\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">More than 100 cannabinoids have been identified within the cannabis plant, that is, chemical compounds found naturally in the plant. One of the most abundant is&nbsp;<strong>cannabidiol (CBD)<\/strong>, which can represent up to 45% of the plant extract. Many of the&nbsp;<em>Cannabis Sativa<\/em>&nbsp;strains give rise to CBD or cannabidiol but do so in small amounts. In fact, only certain branches of the plant contain sufficient concentration of CBD to extract it in a useful way.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The first time that CBD was isolated from the cannabis plant was between 1930 and 1940 by researchers at the University of Illinois (USA). However, it was not until the 1960s when Professor&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Raphael_Mechoulam\" target=\"_blank\" rel=\"noreferrer noopener\">Rafael Mechoulam<\/a>&nbsp;managed to describe its structure and chemical composition. Since 2013, PubMed, an American medical research database, has indexed more than 1,500 studies on cannabidiol. Because of this, many scientists consider&nbsp;<strong>CBD to be one of the most important cannabinoids<\/strong>&nbsp;discovered to date.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\t\t\t\t<div class=\"wp-block-uagb-table-of-contents uagb-toc__align-left uagb-toc__columns-1  uagb-block-849a4cf7      \"\n\t\t\t\t\tdata-scroll= \"1\"\n\t\t\t\t\tdata-offset= \"30\"\n\t\t\t\t\tstyle=\"\"\n\t\t\t\t>\n\t\t\t\t<div class=\"uagb-toc__wrap\">\n\t\t\t\t\t\t<div class=\"uagb-toc__title\">\n\t\t\t\t\t\t\tAll about CBD\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"uagb-toc__list-wrap \">\n\t\t\t\t\t\t<ol class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#cannabidiol-cbd\" class=\"uagb-toc-link__trigger\">Cannabidiol (CBD)<\/a><li class=\"uagb-toc__list\"><a href=\"#infographics-on-cannabidiol\" class=\"uagb-toc-link__trigger\">Infographics on Cannabidiol<\/a><li class=\"uagb-toc__list\"><a href=\"#what-is-cannabidiol-and-what-is-it-for\" class=\"uagb-toc-link__trigger\">What is Cannabidiol and what is it for<\/a><ul class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#studied-therapeutic-effects\" class=\"uagb-toc-link__trigger\">Studied therapeutic effects<\/a><\/li><\/ul><\/li><li class=\"uagb-toc__list\"><a href=\"#clinical-research-on-cbd\" class=\"uagb-toc-link__trigger\">Clinical research on CBD<\/a><li class=\"uagb-toc__list\"><a href=\"#the-entourage-effect-and-cannabidiol\" class=\"uagb-toc-link__trigger\">The entourage effect and Cannabidiol<\/a><li class=\"uagb-toc__list\"><a href=\"#how-to-use-cannabidiol\" class=\"uagb-toc-link__trigger\">How to use cannabidiol<\/a><li class=\"uagb-toc__list\"><a href=\"#cannabidiol-calculator\" class=\"uagb-toc-link__trigger\">Cannabidiol calculator<\/a><li class=\"uagb-toc__list\"><a href=\"#cannabidiol-from-a-chemical-point-of-view\" class=\"uagb-toc-link__trigger\">Cannabidiol from a chemical point of view<\/a><ul class=\"uagb-toc__list\"><li class=\"uagb-toc__list\"><a href=\"#bibliography-on-cannabidiol-and-its-therapeutic-use\" class=\"uagb-toc-link__trigger\">Bibliography on Cannabidiol and its therapeutic use<\/a><\/ul><\/ul><\/ol>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Infographics on Cannabidiol<\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"723\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-1024x723.jpg\" alt=\"Infografia Cannabidiol propiedades terapeuticas | Kalapa Clinic\" class=\"wp-image-21397\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-1024x723.jpg 1024w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-300x212.jpg 300w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK-768x542.jpg 768w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/FICHASCannabinoidesCBD_logoKalapaOK.jpg 1192w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"has-primnamecolour-color has-text-color has-medium-font-size wp-block-heading\">What is Cannabidiol and what is it for<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"wp-block-paragraph\">Compared to other cannabinoids, cannabidiol has gained much importance in the therapeutic field because it lacks the typical psychoactive properties of THC (not acting through the brain&#8217;s CB1 receptors responsible for psychoactivity), which are reduced when using CBD and THC together.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This means similar amounts of CBD and THC (ratio of 1:1 or even higher THC) can be administered without strong adverse side effects due to high amounts of THC (such as the psychoactive effect, tachycardia, anxiety attacks, among others) (Zuardi and al., 1982)&nbsp;<a href=\"https:\/\/www.kalapa-clinic.com\/en\/cannabidiol-cannabis-oil\/#_ftn1\"><sup>[1]<\/sup><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Although much remains to be investigated on the properties of cannabidiol, there are several existing studies that have demonstrated their benefits from a clinical point of view.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Studied therapeutic effects<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>Anxiolytic<\/li><li>Analgesic<\/li><li>Antiemetic<\/li><li>Antiepileptic<\/li><li>Antitumor<\/li><li>Antioxidant<\/li><li>Anti Inflammatory<\/li><li>Antipsychotic<\/li><li>Immunomodulators<\/li><li>Antibacterial and antifungal<\/li><li>Neuroprotective<\/li><li>Antirheumatic<\/li><li>Sleep Inducer<\/li><\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n<div class=\"container genesis-custom-block \">\n\t<div class=\"row\">\n     <div class=\"col-12 text-center\">\n        <h2 class=\"sec-title wow fadeInUp introtitle\" style=\"visibility: visible; animation-name: fadeInUp;\">\n              <span><\/span>\n         <\/h2>\n         <div class=\"introsubtitle sec-title\">Do you want to know more about the use of cannabidiol?<\/div>\n              <p class=\"wow fadeInUp introdescription\" style=\"visibility: visible; animation-name: fadeInUp;\">\n                            We have a team of specialists waiting to answer any questions              <\/p>\n         <\/div>\n     <\/div>\n<\/div>\n\n\n\n\n<div style=\"display: none;\" id=\"treatment_popup_form\">\n\t<div class=\"container\">\n    \t<div class=\"row\">\n        \t<div class=\"col-lg-12\">\n\t\t\t\t<h2>Receive more information<\/h2>\n\t\t\t\t<p>Please fill in your details below and we&#8217;ll send you information about  Cannabidiol.<\/p>\n\t\t\t<\/div>\n\t\t\t<!--<div class=\"col-lg-4\">\n\t\t\t\t<div class=\"f-logo\">\n\t\t\t\t\t<img decoding=\"async\" src=\"\/wp-content\/themes\/understrap\/assets\/images\/logo_kalapa_clinic_retina.png.webp\" alt=\"\">\n                <\/div>\n\t\t\t<\/div>-->\n\t\t<\/div>\n\t<\/div>\t\n\t<div role=\"form\" class=\"wpcf7\" id=\"wpcf7-f21340-o1\" lang=\"es-ES\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/pages\/54143#wpcf7-f21340-o1\" method=\"post\" class=\"wpcf7-form init\" 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wpcf7-text wpcf7-tel wpcf7-validates-as-tel\" aria-invalid=\"false\" placeholder=\"Tel\u00e9fono\" \/><\/span>\n   <\/div>\n<div class=\"wp-block-column\">\n    <span class=\"wpcf7-form-control-wrap your-email\"><input type=\"email\" name=\"your-email\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Tu Email*\" \/><\/span>\n   <\/div>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap text-pais\"><input type=\"text\" name=\"text-pais\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text\" aria-invalid=\"false\" placeholder=\"Pa\u00eds\" \/><\/span><br \/>\n<span class=\"wpcf7-form-control-wrap Padecimiento\"><input type=\"text\" name=\"Padecimiento\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Padecimiento*\" 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de la web. La finalidad de la recogida y tratamiento de los datos personales que nos env\u00edas es para poder informarte sobre los servicios que ofrecemos sobre  tratamientos basados en cannabinoides. La legitimaci\u00f3n se realiza a trav\u00e9s del consentimiento del interesado. Te informamos que los datos que nos facilitas estar\u00e1n ubicados en servidores dentro de la Uni\u00f3n Europea. Podr\u00e1s ejercer tus derechos de acceso, rectificaci\u00f3n, limitaci\u00f3n y suprimir tus datos en cualquier momento. Puedes consultar la informaci\u00f3n adicional y detallada sobre la protecci\u00f3n de tus datos en nuestra <a href=\"https:\/\/www.kalapa-clinic.com\/politica-privacidad\/\"> pol\u00edtica de privacidad<\/a>. <\/FONT><\/p>\n<p style=\"display: none !important;\"><label>&#916;<textarea name=\"_wpcf7_ak_hp_textarea\" cols=\"45\" rows=\"8\" maxlength=\"100\"><\/textarea><\/label><input type=\"hidden\" id=\"ak_js_1\" name=\"_wpcf7_ak_js\" value=\"197\"\/><script>document.getElementById( \"ak_js_1\" ).setAttribute( \"value\", ( new Date() ).getTime() );<\/script><\/p><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div><div data-component=\"cf7rs-success\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Thank you!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><div data-component=\"cf7rs-error\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Error detected!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><\/form><\/div>\t<\/div>\n\n\n\n<div class=\"row justify-content-center\">\n\t<div class=\"col-lg-8 text-center  wow fadeInUp\" style=\"visibility: visible; animation-name: fadeInUp;\">\n\t\t<a data-fancybox data-src=\"#treatment_popup_form\" href=\"javascript:;\" class=\"btn btn-grad btn-lg btn-round\">Pide m\u00e1s informaci\u00f3n sobre el CBD<\/a>\n\t<\/div>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Clinical research on CBD<\/h2>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Although all the benefits of cannabidiol are not fully known, there are studies that have proven its benefits from a clinical point of view. For example, researchers have shown its relationship with the immune system. Thus, it has been verified that, in some cellular lines of the immune system, CBD has the capacity to inhibit the production of some cytokines (IL-8, IL-10, TNF-D, IFNJ).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These studies directly relate CBD to beneficial effects on inflammatory\/autoimmune diseases. Thus, CBD has anti-inflammatory, analgesic, anxiolytic and antipsychotic properties. There are also studies that have related cannabidiol to chronic pain relief or&nbsp;<a href=\"https:\/\/www.dravetfoundation.eu\/el-cannabidiol-puede-ser-la-respuesta-para-miles-de-pacientes-con-epilepsia-que-responden-la-farmacologia-tradicional\/\" target=\"_blank\" rel=\"noreferrer noopener\">to treat epilepsy<\/a>, amongst other illnesses.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Other research has focused on the<strong>&nbsp;effects of cannabidiol on arthritis<\/strong>. One trial with mice showed that a treatment with CBD (both oral and intraperitoneal) managed to block the disease, thus paralyzing its progression. These effects are linked to the immunosuppressive activity and the anti-inflammatory properties of this cannabinoid (Malfait et al., 2000).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a disease such as&nbsp;<strong>cancer<\/strong>,&nbsp;<a href=\"https:\/\/www.kalapa-clinic.com\/en\/cannabis-oil-cancer\/\">&nbsp;cannabis oil in cancer<\/a>&nbsp;causes a sedative effect in most cases and inhibits the transmission of nerve signals associated with pain. It has also been witnessed that CBD reduces the growth of human breast cancer cells in vitro and in vivo in mice, and reduces their invasiveness.<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"600\" height=\"339\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/aceite-canamo-fibromialgia.png\" alt=\"\" class=\"wp-image-17957\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/aceite-canamo-fibromialgia.png 600w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/aceite-canamo-fibromialgia-300x170.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption>Source: Universidad de Sevilla <\/figcaption><\/figure><\/div>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">The entourage effect and Cannabidiol<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The majority of&nbsp;<a href=\"https:\/\/www.kalapa-clinic.com\/en\/scientific-studies-about-cannabis\/\">scientific studies about medical cannabis<\/a>&nbsp;focus on finding out the effects of the different types of cannabinoids, especially, THC and CBD.&nbsp;<strong>The cannabis plant has many more components than their cannabinoids<\/strong>, they have a number other factors&nbsp;<a href=\"https:\/\/www.kalapa-clinic.com\/en\/terpenes-medical-cannabis\/\">like terpenes, that also produce their own effects<\/a>, or secondary effects.&nbsp;<strong>Limiting research to a single cannabinoid reduces the effectiveness of the plant<\/strong>, because what really stands out from the plant are the effects from the combined elements. However, the results of this combination are different for each person. This interaction between the different compounds of cannabis is known as an&nbsp;<strong>entourage effect<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The entourage effect is the interaction between phytocannabinoids such as CBD and the other elements present in the plant. In the case of Cannabis Sativa L, interactions between terpenes, flavonoids and at the time of ingestion, with endocannabinoids such as anandamide, are being studied.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is limited information about the entourage effect, however, Dr. Ethan Russo from the University of Massachusetts published<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1476-5381.2011.01238.x\/full\">&nbsp;a study<\/a>&nbsp;on the synergy of phytocannabinoids and terpenes back in 2011.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sometimes there are pathologies that cannot be treated with just one cannabinoid. The&nbsp;<strong>synergy between different cannabinoids also produce the entourage effect<\/strong>, which is very useful for treating diseases in which a single component is not enough. Several research studies explain the main medicinal benefits of cannabis, such as its analgesic effects. However, there are other studies that support CBD and other components of cannabis combined, which can, increase its benefits, reduce adverse effects, and produce less toxicity than with THC alone.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The range of effects of phytocannabinoids is very wide which is why it is necessary to continue investigating their therapeutic potentials<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That is why several therapeutic references focus on oils with a full spectrum, to promote the entourage effect. It is being found in therapeutic practice that the difference between the use of isolated CBD, requires people to apply a dose 3 times higher than when a full spectrum is administered.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On the other hand, when terpenes or flavonoids are subsequently added to CBD, the entourage effect is greatly diminished.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is currently known that&nbsp;<strong>cannabinoids are useful for treating depression, anxiety, insomnia, dementia and addiction, among others<\/strong>. Russo also addressed these pathologies in his studies and concluded that limonene and linalool could contribute by enhancing the effects of CBD.&nbsp;<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/efecto-sequito-effetdentourage-entourage-effect-Entourage-Effekt-effetto-seguito.jpg\" alt=\"\" class=\"wp-image-18186\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/efecto-sequito-effetdentourage-entourage-effect-Entourage-Effekt-effetto-seguito.jpg 600w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/10\/efecto-sequito-effetdentourage-entourage-effect-Entourage-Effekt-effetto-seguito-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure><\/div>\n\n\n<div class=\"container genesis-custom-block \">\n\t<div class=\"row\">\n     <div class=\"col-12 text-center\">\n        <h2 class=\"sec-title wow fadeInUp introtitle\" style=\"visibility: visible; animation-name: fadeInUp;\">\n              <span><\/span>\n         <\/h2>\n         <div class=\"introsubtitle sec-title\">Do you want to know more about the use of cannabidiol?<\/div>\n              <p class=\"wow fadeInUp introdescription\" style=\"visibility: visible; animation-name: fadeInUp;\">\n                            We have a team of specialists waiting to answer any questions              <\/p>\n         <\/div>\n     <\/div>\n<\/div>\n\n\n\n\n<div style=\"display: none;\" id=\"treatment_popup_form\">\n\t<div class=\"container\">\n    \t<div class=\"row\">\n        \t<div class=\"col-lg-12\">\n\t\t\t\t<h2>Receive more information<\/h2>\n\t\t\t\t<p>Please fill in your details below and we&#8217;ll send you information about  Cannabidiol.<\/p>\n\t\t\t<\/div>\n\t\t\t<!--<div class=\"col-lg-4\">\n\t\t\t\t<div class=\"f-logo\">\n\t\t\t\t\t<img decoding=\"async\" src=\"\/wp-content\/themes\/understrap\/assets\/images\/logo_kalapa_clinic_retina.png.webp\" alt=\"\">\n                <\/div>\n\t\t\t<\/div>-->\n\t\t<\/div>\n\t<\/div>\t\n\t<div role=\"form\" class=\"wpcf7\" id=\"wpcf7-f21340-o2\" lang=\"es-ES\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/pages\/54143#wpcf7-f21340-o2\" method=\"post\" class=\"wpcf7-form init\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"21340\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"5.5.6\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"es_ES\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f21340-o2\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap your-name\"><input type=\"text\" name=\"your-name\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Nombre Completo*\" \/><\/span><\/p>\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\">\n     <span class=\"wpcf7-form-control-wrap tel-431\"><input type=\"tel\" name=\"tel-431\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-tel wpcf7-validates-as-tel\" aria-invalid=\"false\" placeholder=\"Tel\u00e9fono\" \/><\/span>\n   <\/div>\n<div class=\"wp-block-column\">\n    <span class=\"wpcf7-form-control-wrap your-email\"><input type=\"email\" name=\"your-email\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Tu Email*\" \/><\/span>\n   <\/div>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap text-pais\"><input type=\"text\" name=\"text-pais\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text\" aria-invalid=\"false\" placeholder=\"Pa\u00eds\" \/><\/span><br \/>\n<span class=\"wpcf7-form-control-wrap Padecimiento\"><input type=\"text\" name=\"Padecimiento\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Padecimiento*\" \/><\/span><\/p>\n<p><span class=\"wpcf7-form-control-wrap your-message\"><textarea name=\"your-message\" cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Tu mensaje\"><\/textarea><\/span><\/p>\n<p><input type=\"submit\" value=\"ENVIAR\" class=\"wpcf7-form-control has-spinner wpcf7-submit btn btn-green sndbtntreatment\" \/><\/p>\n<p><span class=\"wpcf7-form-control-wrap acceptance-LOPD\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><input type=\"checkbox\" name=\"acceptance-LOPD\" value=\"1\" aria-invalid=\"false\" \/><\/span><\/span><\/span> Si, acepto la <a style=\"color:#4da8ca;text-decoration:underline;\" href=\"\/politica-privacidad\/\">pol\u00edtica de privacidad<\/a> de Kalapa Clinic.<\/p>\n<p><FONT SIZE=1>Kalapa Clinic informa que los datos de car\u00e1cter personal que proporciones rellenando este formulario ser\u00e1n tratados por Grupo HS3 Project Development, S.L. como responsable de la web. La finalidad de la recogida y tratamiento de los datos personales que nos env\u00edas es para poder informarte sobre los servicios que ofrecemos sobre  tratamientos basados en cannabinoides. La legitimaci\u00f3n se realiza a trav\u00e9s del consentimiento del interesado. Te informamos que los datos que nos facilitas estar\u00e1n ubicados en servidores dentro de la Uni\u00f3n Europea. Podr\u00e1s ejercer tus derechos de acceso, rectificaci\u00f3n, limitaci\u00f3n y suprimir tus datos en cualquier momento. Puedes consultar la informaci\u00f3n adicional y detallada sobre la protecci\u00f3n de tus datos en nuestra <a href=\"https:\/\/www.kalapa-clinic.com\/politica-privacidad\/\"> pol\u00edtica de privacidad<\/a>. <\/FONT><\/p>\n<p style=\"display: none !important;\"><label>&#916;<textarea name=\"_wpcf7_ak_hp_textarea\" cols=\"45\" rows=\"8\" maxlength=\"100\"><\/textarea><\/label><input type=\"hidden\" id=\"ak_js_2\" name=\"_wpcf7_ak_js\" value=\"187\"\/><script>document.getElementById( \"ak_js_2\" ).setAttribute( \"value\", ( new Date() ).getTime() );<\/script><\/p><div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div><div data-component=\"cf7rs-success\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Thank you!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><div data-component=\"cf7rs-error\" data-html=\"&lt;h3 style=&quot;text-align: center;&quot;&gt;Error detected!&lt;\/h3&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;!--message--&gt;&lt;\/p&gt;\n&lt;p style=&quot;text-align: center;&quot;&gt;&lt;a href=&quot;#&quot; data-component=&quot;cf7rs-close&quot; class=&quot;&quot;&gt;Ok&lt;\/a&gt;&lt;\/p&gt;\" data-close-delay=\"3000\" data-placement=\"in-modal\" ><\/div><\/form><\/div>\t<\/div>\n\n\n\n<div class=\"row justify-content-center\">\n\t<div class=\"col-lg-8 text-center  wow fadeInUp\" style=\"visibility: visible; animation-name: fadeInUp;\">\n\t\t<a data-fancybox data-src=\"#treatment_popup_form\" href=\"javascript:;\" class=\"btn btn-grad btn-lg btn-round\">Pide m\u00e1s informaci\u00f3n sobre el CBD<\/a>\n\t<\/div>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use cannabidiol<\/h2>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">There are different products on the market that contain CBD taken from certified hemp. CBD Oil is one of the best-known products. The oil can be ingested or used as a compound in creams and ointments, sprays and teas. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The effect of the cannabidiol seems to take between 15 and 30 minutes. There are also CBD capsules or infusions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the case of the sprays, its operation is very simple. It is a question of placing the nozzle below the tongue (sublingual) and taking the dose prescribed by the specialist. In the case of infusions, it is a matter of preparing a conventional infusion and adding some type of milk or cream to help the cannabinoids dissolve correctly.<\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Although CBD is still being researched in countries around the world, in Spain products composed of CBD and THC (the latter at a level below 0.2%) can be consumed legally and without a doctor&#8217;s prescription in order to buy it.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In Spain there is only one drug composed of cannabidiol called Sativex, this is a pharmacological solution developed by GW Pharmaceutical composed of&nbsp;<strong>CBD and THC (ratio 1:1),<\/strong>&nbsp;created for the treatment of pain and spasticity in people with multiple sclerosis.&nbsp;<a href=\"https:\/\/www.kalapa-clinic.com\/en\/cannabidiol-cannabis-oil\/#_ftn3\"><sup>[3]<\/sup><\/a><\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<figure class=\"wp-block-pullquote is-style-default\" style=\"border-color:#C1C1C1\"><blockquote class=\"has-text-color\" style=\"color:#5a595c\"><p>The effect of Cannabidiol takes 15 to 30 minutes to appear. Depending on the route of administration.<\/p><\/blockquote><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Cannabidiol calculator<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">When using cannabidiol, one of the main points is knowing how to quantify the milligrams of cannabidiol that the patient should ingest. Depending on the concentration of cannabidiol in the CBD oil, the dose to be administered can be determined.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In order to help the patient to have a first orientation of these doses, there are web pages that offer a CBD oil calculator , based on the analyses that they have made to their products, which allows to quantify the CBD in each drop.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Obviously, from Kalapa Clinic we recommend the help of a health professional in the administration and dosage of any substance that a patient wants to take.<\/p>\n\n\n\n<div style=\"text-align:center\" class=\"wp-block-genesis-blocks-gb-button gb-block-button\"><a href=\"https:\/\/www.mycbd.com\/calculating-cbd-oil\/\" target=\"_blank\" rel=\"noopener noreferrer\" class=\"gb-button gb-button-shape-circular gb-button-size-medium\" style=\"color:#ffffff;background-color:#68B2A0\">Cannabidiol Calculator online<\/a><\/div>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"600\" height=\"315\" src=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/estructura-molecular-cannabidiol.png\" alt=\"estructura molecular cannabidiol\" class=\"wp-image-19833\" srcset=\"https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/estructura-molecular-cannabidiol.png 600w, https:\/\/www.kalapa-clinic.com\/wp-content\/uploads\/2020\/11\/estructura-molecular-cannabidiol-300x158.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><figcaption>Estructura Molecular del Cannabidiol<\/figcaption><\/figure><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Cannabidiol from a chemical point of view<\/h2>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-columns gb-layout-columns-2 gb-2-col-equal\"><div class=\"gb-layout-column-wrap gb-block-layout-column-gap-2 gb-is-responsive-column\">\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">Cannabidiol is chemically expressed as 2-(6-isopropenyl-3-methyl-2-cyclohexen-1-yl)-5-Pentyl-1.3-Benzenediol.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is integrated with the family of terpene phenols, substances that usually have a carbocyclic structure with 21 carbons and are usually formed by three rings: cyclohexene, Tetrahydropyran\u00a0and benzene<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Its molecular form is C21H30O2 and its molecular weight is 314,4636. Its melting point is 66 \u00b0 C and its boiling point is 180 \u00ba C. At room temperature it forms a reddish crystallization.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>It is a molecule that is insoluble in water, but soluble in organic solvents and in fats.<\/strong>\u00a0<a href=\"https:\/\/www.kalapa-clinic.com\/en\/cannabidiol-cannabis-oil\/#_ftn4\"><sup>[4]<\/sup><\/a><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-genesis-blocks-gb-column gb-block-layout-column\"><div class=\"gb-block-layout-column-inner\">\n<p class=\"wp-block-paragraph\">The therapeutic effect caused by cannabidiol is due to its solubility since it interferes with the nociceptive response of nerve cells, whose cellular structure is highly lipidic. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Due to this solubility, homemade preparations requiring this product must have a medium-high fat content, using, for example, milk or oil as a base. For a therapeutic effect, it is always preferable to use natural and organic oils as bases.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For a therapeutic effect it is always preferable to use bases in organic natural oils.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Among the preparations with a high coefficient of effectiveness are those with a full spectrum (Full Spectrum).<\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<figure class=\"wp-block-pullquote is-style-default\"><blockquote><p>CBD is an INSOLUBLE molecule in water, but soluble in organic solvents and fats<\/p><\/blockquote><\/figure>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h3 class=\"wp-block-heading\">Bibliography on Cannabidiol and its therapeutic use<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">[1]&nbsp;Zuardi y cols.,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/6285406\/\" target=\"_blank\" rel=\"noreferrer noopener\">Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects<\/a>. 1982.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[2] Di Marzo V, Pisticelli F.&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4604172\/\" target=\"_blank\" rel=\"noreferrer noopener\">The endocannabinoid system and its modulation by phytocannabinoids.<\/a> Neurotherapeutics. 2015, 12(4):692-698.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[3]&nbsp;OREJA-GUEVARA, C.&nbsp;<a href=\"https:\/\/www.researchgate.net\/profile\/Celia_Oreja-Guevara\/publication\/231211591_Treatment_of_spasticity_in_multiple_sclerosis_New_perspectives_regarding_the_use_of_cannabinoids\/links\/0fcfd5117ca9f55d97000000\/Treatment-of-spasticity-in-multiple-sclerosis-New-perspectives-regarding-the-use-of-cannabinoids.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Tratamiento de la espasticidad en la esclerosis m\u00faltiple: nuevas perspectivas con el uso de cannabinoides<\/a>. Rev Neurol 2012; 55: 421-30<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">[4] SEIC.&nbsp;<a href=\"http:\/\/www.seic.es\/wp-content\/uploads\/2013\/10\/guiab%C3%A1sicacannab.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Gu\u00eda B\u00e1sica sobre los cannabinoides<\/a>. 2002.<\/p>\n<\/div><\/div>\n\n\n<div class=\"container genesis-custom-block \">\n\t<div class=\"row\">\n     <div class=\"col-12 text-center\">\n        <h2 class=\"sec-title wow fadeInUp introtitle\" style=\"visibility: visible; animation-name: fadeInUp;\">\n              <span><\/span>\n         <\/h2>\n         <div class=\"introsubtitle sec-title\">Do you want to know more about the use of cannabidiol?<\/div>\n              <p class=\"wow fadeInUp introdescription\" style=\"visibility: visible; animation-name: fadeInUp;\">\n                            We have a team of specialists waiting to answer any questions              <\/p>\n         <\/div>\n     <\/div>\n<\/div>\n\n\n\n\n<div style=\"display: none;\" id=\"treatment_popup_form\">\n\t<div class=\"container\">\n    \t<div class=\"row\">\n        \t<div class=\"col-lg-12\">\n\t\t\t\t<h2>Receive more information<\/h2>\n\t\t\t\t<p>Please fill in your details below and we&#8217;ll send you information about  Cannabidiol.<\/p>\n\t\t\t<\/div>\n\t\t\t<!--<div class=\"col-lg-4\">\n\t\t\t\t<div class=\"f-logo\">\n\t\t\t\t\t<img decoding=\"async\" src=\"\/wp-content\/themes\/understrap\/assets\/images\/logo_kalapa_clinic_retina.png.webp\" alt=\"\">\n                <\/div>\n\t\t\t<\/div>-->\n\t\t<\/div>\n\t<\/div>\t\n\t<div role=\"form\" class=\"wpcf7\" id=\"wpcf7-f21340-o3\" lang=\"es-ES\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/pages\/54143#wpcf7-f21340-o3\" method=\"post\" class=\"wpcf7-form init\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"21340\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"5.5.6\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"es_ES\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f21340-o3\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap your-name\"><input type=\"text\" name=\"your-name\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Nombre Completo*\" \/><\/span><\/p>\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\">\n     <span class=\"wpcf7-form-control-wrap tel-431\"><input type=\"tel\" name=\"tel-431\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-tel wpcf7-validates-as-tel\" aria-invalid=\"false\" placeholder=\"Tel\u00e9fono\" \/><\/span>\n   <\/div>\n<div class=\"wp-block-column\">\n    <span class=\"wpcf7-form-control-wrap your-email\"><input type=\"email\" name=\"your-email\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Tu Email*\" \/><\/span>\n   <\/div>\n<\/div>\n<p><span class=\"wpcf7-form-control-wrap text-pais\"><input type=\"text\" name=\"text-pais\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text\" aria-invalid=\"false\" placeholder=\"Pa\u00eds\" \/><\/span><br \/>\n<span class=\"wpcf7-form-control-wrap Padecimiento\"><input type=\"text\" name=\"Padecimiento\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Padecimiento*\" \/><\/span><\/p>\n<p><span class=\"wpcf7-form-control-wrap your-message\"><textarea name=\"your-message\" cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Tu mensaje\"><\/textarea><\/span><\/p>\n<p><input type=\"submit\" value=\"ENVIAR\" class=\"wpcf7-form-control has-spinner wpcf7-submit btn btn-green sndbtntreatment\" \/><\/p>\n<p><span class=\"wpcf7-form-control-wrap acceptance-LOPD\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><input type=\"checkbox\" name=\"acceptance-LOPD\" value=\"1\" aria-invalid=\"false\" \/><\/span><\/span><\/span> Si, acepto la <a style=\"color:#4da8ca;text-decoration:underline;\" href=\"\/politica-privacidad\/\">pol\u00edtica de privacidad<\/a> de Kalapa Clinic.<\/p>\n<p><FONT SIZE=1>Kalapa Clinic informa que los datos de car\u00e1cter personal que proporciones rellenando este formulario ser\u00e1n tratados por Grupo HS3 Project Development, S.L. como responsable de la web. La finalidad de la recogida y tratamiento de los datos personales que nos env\u00edas es para poder informarte sobre los servicios que ofrecemos sobre  tratamientos basados en cannabinoides. La legitimaci\u00f3n se realiza a trav\u00e9s del consentimiento del interesado. Te informamos que los datos que nos facilitas estar\u00e1n ubicados en servidores dentro de la Uni\u00f3n Europea. Podr\u00e1s ejercer tus derechos de acceso, rectificaci\u00f3n, limitaci\u00f3n y suprimir tus datos en cualquier momento. 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Infographics on Cannabidiol What is Cannabidiol and what is it for Compared to other cannabinoids, cannabidiol has gained much importance in the therapeutic field because it lacks the typical psychoactive properties of THC (not acting through the brain&#8217;s CB1 receptors responsible for psychoactivity), which are reduced when using CBD and THC together. 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