News: Inhaled CBD inhibits tumor growth in lung cancer

Lung cancer (bronchial carcinoma) is not only one of the most common cancers worldwide – lung cancer also carries the highest risk of dying from cancer. Despite significant improvements in the treatment of lung cancer, current therapeutic interventions are only partially effective, making the search for treatment alternatives important.

A new study in mice suggests that inhaled CBD reduces the growth of lung cancer.

CBD and cancer

In recent years, cannabinoids have been studied extensively for their potential effects against tumor growth. Previous results showed that cannabidiol (CBD) can inhibit growth in mouse models of skin cancer (melanoma) and brain tumors (glioblastoma). It is believed that CBD can curb vascularization in tumors, thus hindering growth.

In a new study, researchers tested inhaled CBD in the treatment of lung cancer and investigated whether this potential effect could reduce the number of cancer stem cells and inhibit new vessel formation in tumors. (1)

“Our results showed that CBD reduced tumor growth rate and suppressed the expression of CD44 and the angiogenic factors VEGF and P-selectin. These results suggest for the first time that inhaled CBD may inhibit lung cancer growth by suppressing CD44 and angiogenesis,” said the study authors*. (1)

Lung cancer: the most dangerous cancer

With about 1.76 million deaths, bronchial carcinomas claimed the most lives worldwide – cancer mortality is very high. The cancers colorectal and gastric cancer follow at a considerable distance, with around 881,000 and 783,000 deaths, respectively. Together with liver and breast cancer, these cancers accounted for more than half of all cancer-related deaths worldwide. (2)

In 2019, approximately 23,546 women and 32,701 men developed lung cancer in Germany, and 16,999 women and 27,882 men died from this disease. It is striking that the disease and death rates develop in opposite directions for the two sexes: since the end of the 1990s, they have risen continuously for women, while they have declined for men over the same period. This different development can be attributed to the change in smoking habits that has already occurred some time ago and is likely to continue. (3)

The most important cause and thus the greatest risk factor for the development of malignant tumors of the lung is smoking.

Sources:

(1) Salles ÉL, Naeini SE, Khodadadi H, Bhandari B, Rezaee S, Threlkeld E, Rogers HM, Costigliola V, Terry AV Jr, Hess DC, Deb S, Deb SP, Yeudall WA, Yu JC, Wang LP, Baban B. Inhalant cannabidiol impedes tumor growth through decreased tumor stemness and impaired angiogenic switch in NCI-H1437-induced human lung cancer model. Hum Cell. 2023 May;36(3):1204-1210. doi: 10.1007/s13577-023-00869-8. Epub 2023 Feb 3. PMID: 36737540.

(2) Journal Onkologie

(3) Robert Koch Institut: Krebsdaten

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Información creada y revisada por expertos en Cannabis Medicinal. Todas las publicaciones se basan en investigaciones médicas y con referencias clínicas.